WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130256
CAS#: N/A
Description: Oxacyclododecindione is an inhibitor of the expression of SEAP induced by IL-4. Oxacyclododecindione prevents the binding of activated STAT6 transcription factors with DNA, which in turn, blocks the IL-4 signaling pathway. Oxacyclododecindione shows promise in treating inflammatory diseases.
Hodoodo Cat#: H130256
Name: Oxacyclododecindione
CAS#: N/A
Chemical Formula: C18H21ClO6
Exact Mass: 368.10
Molecular Weight: 368.810
Elemental Analysis: C, 58.62; H, 5.74; Cl, 9.61; O, 26.03
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: Oxacyclododecindione
IUPAC/Chemical Name: (E)-14-chloro-5,11,13-trihydroxy-4,5,9-trimethyl-4,5,6,7-tetrahydro-2H-benzo[d][1]oxacyclododecine-2,10(1H)-dione
InChi Key: CKSXTSLBLCBNFG-WEVVVXLNSA-N
InChi Code: InChI=1S/C18H21ClO6/c1-9-5-4-6-18(3,24)10(2)25-14(22)7-11-15(17(9)23)12(20)8-13(21)16(11)19/h5,8,10,20-21,24H,4,6-7H2,1-3H3/b9-5+
SMILES Code: O=C(CC1=C(Cl)C(O)=CC(O)=C12)OC(C)C(C)(O)CC/C=C(C)/C2=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 368.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Erkel G, Belahmer H, Serwe A, Anke T, Kunz H, Kolshorn H, Liermann J, Opatz T. Oxacyclododecindione, a novel inhibitor of IL-4 signaling from Exserohilum rostratum. J Antibiot (Tokyo). 2008 May;61(5):285-90. doi: 10.1038/ja.2008.40. PMID: 18653993.
2. Tauber J, Rohr M, Walter T, Erkel G, Opatz T. Total synthesis of two potent anti-inflammatory macrolactones of the oxacyclododecindione type. Org Biomol Chem. 2015 Jul 28;13(28):7813-21. doi: 10.1039/c5ob01044f. Epub 2015 Jun 24. Erratum in: Org Biomol Chem. 2015 Sep 7;13(33):8945-6. PMID: 26106910.
3. Henke J, Erkel G, Brochhausen C, Kleinert H, Schwarting A, Menke J, Pautz A. The fungal lactone oxacyclododecindione is a potential new therapeutic substance in the treatment of lupus-associated kidney disease. Kidney Int. 2014 Oct;86(4):780-9. doi: 10.1038/ki.2014.109. Epub 2014 Apr 9. PMID: 24717299.