WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130255
CAS#: 634169-12-3
Description: SNI-1 inhibits the binding of NEMO-CARP-1 and increases the susceptibility of cancer cells to chemotherapy.
Hodoodo Cat#: H130255
Name: SNI-1
CAS#: 634169-12-3
Chemical Formula: C16H14N4O3S
Exact Mass: 342.08
Molecular Weight: 342.370
Elemental Analysis: C, 56.13; H, 4.12; N, 16.36; O, 14.02; S, 9.36
This product is not in stock, which may be available by custom synthesis.
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Synonym: SNI-1; SNI1; SNI 1; (SNI)-1
IUPAC/Chemical Name: 1-(3,4-dihydroxyphenyl)-2-((1-(p-tolyl)-1H-tetrazol-5-yl)thio)ethan-1-one
InChi Key: MVIWFFDPSPYDKQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H14N4O3S/c1-10-2-5-12(6-3-10)20-16(17-18-19-20)24-9-15(23)11-4-7-13(21)14(22)8-11/h2-8,21-22H,9H2,1H3
SMILES Code: CC1=CC=C(N2N=NN=C2SCC(C3=CC=C(O)C(O)=C3)=O)C=C1
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 342.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Venkatesh J, Sekhar SC, Cheriyan VT, Muthu M, Meister P, Levi E, Dzinic S, Gauld JW, Polin LA, Rishi AK. Antagonizing binding of cell cycle and apoptosis regulatory protein 1 (CARP-1) to the NEMO/IKKγ protein enhances the anticancer effect of chemotherapy. J Biol Chem. 2020 Mar 13;295(11):3532-3552. doi: 10.1074/jbc.RA119.009898. Epub 2020 Feb 4. PMID: 32024692; PMCID: PMC7076213.