WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H122928
CAS#: 2276-94-0
Description: Allolithocholic acid is a secondary allomonohydroxy bile acid.
Hodoodo Cat#: H122928
Name: Allolithocholic Acid
CAS#: 2276-94-0
Chemical Formula: C24H40O3
Exact Mass: 376.30
Molecular Weight: 376.580
Elemental Analysis: C, 76.55; H, 10.71; O, 12.75
Synonym: 3α-hydroxy-5α-Cholanoic Acid; allo-LCA
IUPAC/Chemical Name: (R)-4-((3R,5S,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid
InChi Key: SMEROWZSTRWXGI-NWFSOSCSSA-N
InChi Code: InChI=1S/C24H40O3/c1-15(4-9-22(26)27)19-7-8-20-18-6-5-16-14-17(25)10-12-23(16,2)21(18)11-13-24(19,20)3/h15-21,25H,4-14H2,1-3H3,(H,26,27)/t15-,16+,17-,18+,19-,20+,21+,23+,24-/m1/s1
SMILES Code: C[C@@H]([C@]1(CC[C@]2([C@@]3(CC[C@]4(C[C@@H](CC[C@@]4([C@]3(CC[C@@]21C)[H])C)O)[H])[H])[H])[H])CCC(O)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 376.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Song B, Li P, Xu H, Wang Z, Yuan J, Zhang B, Lv Z, Song Z, Guo Y. Effects of rearing system and antibiotic treatment on immune function, gut microbiota and metabolites of broiler chickens. J Anim Sci Biotechnol. 2022 Dec 16;13(1):144. doi: 10.1186/s40104-022-00788-y. PMID: 36522791; PMCID: PMC9756480.
2: Ilgisonis EV, Shalina R, Kasum-Zade N, Burkova KG, Trifonova OP, Maslov DL, Kaysheva AL, Markin SS. Metabolomic Markers for Predicting Preeclampsia in the First Trimester of Pregnancy: A Retrospective Study. Molecules. 2022 Apr 12;27(8):2475. doi: 10.3390/molecules27082475. PMID: 35458675; PMCID: PMC9025490.
3: Bremmelgaard A, Almé B. Analysis of plasma bile acid profiles in patients with liver diseases associated with cholestasis. Scand J Gastroenterol. 1980;15(5):593-600. doi: 10.3109/00365528009182221. PMID: 7444367.
4: Almé B, Bremmelgaard A, Sjövall J, Thomassen P. Analysis of metabolic profiles of bile acids in urine using a lipophilic anion exchanger and computerized gas-liquid chromatorgaphy-mass spectrometry. J Lipid Res. 1977 May;18(3):339-62. PMID: 864325.
5: Lee JW, Cowley ES, Wolf PG, Doden HL, Murai T, Caicedo KYO, Ly LK, Sun F, Takei H, Nittono H, Daniel SL, Cann I, Gaskins HR, Anantharaman K, Alves JMP, Ridlon JM. Formation of secondary allo-bile acids by novel enzymes from gut Firmicutes. Gut Microbes. 2022 Jan-Dec;14(1):2132903. doi: 10.1080/19490976.2022.2132903. PMID: 36343662; PMCID: PMC9645264.
