WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130260
CAS#: N/A
Description: GAP112-RBD is an agent consisting of a TLR4 agonist conjugated to an antigen to form a vaccine for use against SARS-CoV-2.
Hodoodo Cat#: H130260
Name: GAP112-RBD
CAS#: N/A
Chemical Formula: C99H188N5O25P
Exact Mass: 1,878.33
Molecular Weight: 1,879.580
Elemental Analysis: C, 63.26; H, 10.08; N, 3.73; O, 21.28; P, 1.65
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Synonym: GAP112-RBD; GAP112 RBD; GAP 112-RBD; GAP-112-RBD
IUPAC/Chemical Name: (2R,3S,4R,5R,6R)-2-(18-(aminooxy)-3,17-dioxo-2,7,10,13-tetraoxa-4,16-diazaoctadecyl)-5-((R)-3-(dodecanoyloxy)tetradecanamido)-6-(2-((R)-3-(dodecanoyloxy)tetradecanamido)-3-hydroxy-2-(hydroxymethyl)propoxy)-3-(phosphonooxy)tetrahydro-2H-pyran-4-yl (R)-3-(dodecanoyloxy)tetradecanoate
InChi Key: FQODWBWDPOCONY-COHVJAALSA-N
InChi Code: InChI=1S/C99H188N5O25P/c1-7-13-19-25-31-37-43-49-55-61-83(124-90(110)64-58-52-46-40-34-28-22-16-10-4)75-87(107)103-94-96(128-93(113)77-85(63-57-51-45-39-33-27-21-15-9-3)126-92(112)66-60-54-48-42-36-30-24-18-12-6)95(129-130(115,116)117)86(78-121-98(114)102-68-70-119-72-74-120-73-71-118-69-67-101-89(109)79-123-100)127-97(94)122-82-99(80-105,81-106)104-88(108)76-84(62-56-50-44-38-32-26-20-14-8-2)125-91(111)65-59-53-47-41-35-29-23-17-11-5/h83-86,94-97,105-106H,7-82,100H2,1-6H3,(H,101,109)(H,102,114)(H,103,107)(H,104,108)(H2,115,116,117)/t83-,84-,85-,86-,94-,95-,96-,97-/m1/s1
SMILES Code: CCCCCCCCCCC[C@@H](OC(CCCCCCCCCCC)=O)CC(O[C@H]1[C@H](OP(O)(O)=O)[C@@H](COC(NCCOCCOCCOCCNC(CON)=O)=O)O[C@@H](OCC(CO)(NC(C[C@H](OC(CCCCCCCCCCC)=O)CCCCCCCCCCC)=O)CO)[C@@H]1NC(C[C@H](OC(CCCCCCCCCCC)=O)CCCCCCCCCCC)=O)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 1,879.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Ding D, Wen Y, Liao CM, Yin XG, Zhang RY, Wang J, Zhou SH, Zhang ZM, Zou YK, Gao XF, Wei HW, Yang GF, Guo J. Self-Adjuvanting Protein Vaccine Conjugated with a Novel Synthetic TLR4 Agonist on Virus-Like Liposome Induces Potent Immunity against SARS-CoV-2. J Med Chem. 2023 Jan 26;66(2):1467-1483. doi: 10.1021/acs.jmedchem.2c01642. Epub 2023 Jan 10. PMID: 36625758; PMCID: PMC9844103.