WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130261
CAS#: N/A
Description: SJ43489 is a l (PD)-based LCK-directing PD-PROTAC.
Hodoodo Cat#: H130261
Name: SJ43489
CAS#: N/A
Chemical Formula: C38H44ClN11O4S
Exact Mass: 785.30
Molecular Weight: 786.350
Elemental Analysis: C, 58.04; H, 5.64; Cl, 4.51; N, 19.59; O, 8.14; S, 4.08
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Synonym: SJ43489; SJ 43489; SJ-43489
IUPAC/Chemical Name: N-(2-chloro-6-methylphenyl)-2-((6-(4-(4-(4-(4-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)phenyl)piperazin-1-yl)-4-oxobutyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide
InChi Key: UBWYPSMSVKLWNN-UHFFFAOYSA-N
InChi Code: InChI=1S/C38H44ClN11O4S/c1-25-5-3-6-29(39)35(25)45-36(53)30-24-40-37(55-30)43-31-23-32(42-26(2)41-31)48-17-15-46(16-18-48)13-4-7-34(52)49-21-19-47(20-22-49)27-8-10-28(11-9-27)50-14-12-33(51)44-38(50)54/h3,5-6,8-11,23-24H,4,7,12-22H2,1-2H3,(H,45,53)(H,44,51,54)(H,40,41,42,43)
SMILES Code: O=C(C1=CN=C(NC2=NC(C)=NC(N3CCN(CCCC(N4CCN(C5=CC=C(N(C(N6)=O)CCC6=O)C=C5)CC4)=O)CC3)=C2)S1)NC7=C(C)C=CC=C7Cl
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 786.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Jarusiewicz JA, Yoshimura S, Mayasundari A, Actis M, Aggarwal A, McGowan K, Yang L, Li Y, Fu X, Mishra V, Heath R, Narina S, Pruett-Miller SM, Nishiguchi G, Yang JJ, Rankovic Z. Phenyl Dihydrouracil: An Alternative Cereblon Binder for PROTAC Design. ACS Med Chem Lett. 2023 Jan 4;14(2):141-145. doi: 10.1021/acsmedchemlett.2c00436. PMID: 36793425; PMCID: PMC9923830.