WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130272
CAS#: 2276787-79-0
Description: Bevonescein, also known as ALM-488, is a peptide-dye conjugate used for the visualization of nerves (most commonly facial and neck nerves) during surgery.
Hodoodo Cat#: H130272
Name: Bevonescein
CAS#: 2276787-79-0
Chemical Formula: C112H144N22O32
Exact Mass: 2,309.03
Molecular Weight: 2,310.510
Elemental Analysis: C, 58.22; H, 6.28; N, 13.34; O, 22.16
This product is not in stock, which may be available by custom synthesis.
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Synonym: Bevonescein; ALM-488
IUPAC/Chemical Name: N2-(3',6'-dihydroxy-3-oxo-3H-spiro[[2]benzofuran-1,9'-xanthene]-5-carbonyl)-Gln-Val-Pro-Trp-Glu-Glu-Pro-Tyr-Tyr-Val-Val-Lys-Lys-Ser-Ser-Gly-Gly-NH2
InChi Key: QOJOBKQIRSTJPM-VAIPJCBFSA-N
InChi Code: InChI=1S/C112H144N22O32/c1-56(2)92(107(160)123-74(18-10-12-42-114)97(150)121-73(17-9-11-41-113)98(151)129-82(55-136)104(157)128-81(54-135)96(149)119-53-89(143)118-52-88(116)142)131-108(161)93(57(3)4)130-103(156)79(46-60-23-28-64(138)29-24-60)125-101(154)78(45-59-21-26-63(137)27-22-59)126-105(158)83-19-13-43-133(83)109(162)77(37-40-91(146)147)124-99(152)76(36-39-90(144)145)122-102(155)80(48-62-51-117-72-16-8-7-15-67(62)72)127-106(159)84-20-14-44-134(84)110(163)94(58(5)6)132-100(153)75(35-38-87(115)141)120-95(148)61-25-32-69-68(47-61)111(164)166-112(69)70-33-30-65(139)49-85(70)165-86-50-66(140)31-34-71(86)112/h7-8,15-16,21-34,47,49-51,56-58,73-84,92-94,117,135-140H,9-14,17-20,35-46,48,52-55,113-114H2,1-6H3,(H2,115,141)(H2,116,142)(H,118,143)(H,119,149)(H,120,148)(H,121,150)(H,122,155)(H,123,160)(H,124,152)(H,125,154)(H,126,158)(H,127,159)(H,128,157)(H,129,151)(H,130,156)(H,131,161)(H,132,153)(H,144,145)(H,146,147)/t73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,92-,93-,94-/m0/s1
SMILES Code: O=C(N[C@@H](C(C)C)C(N1[C@@H](CCC1)C(N[C@@H](CC2=CNC3=CC=CC=C23)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(O)=O)C(N4[C@@H](CCC4)C(N[C@@H](CC5=CC=C(C=C5)O)C(N[C@@H](CC6=CC=C(C=C6)O)C(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@@H](CO)C(NCC(NCC(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCC(N)=O)NC(C7=CC=C(C8=C7)C9(C%10=C(OC%11=C9C=CC(O)=C%11)C=C(O)C=C%10)OC8=O)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 2,310.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. https://clinicaltrials.gov/ct2/show/NCT05377554
2. https://www.cancer.gov/about-cancer/treatment/clinical-trials/search/v?id=NCI-2020-05330&r=1
3. Crawford KL, Lee YJ, Hom M, Rosenthal EL, Orosco RK, Nguyen QT. Identification of Degenerated Murine Facial Nerves With Fluorescence Labeling After Transection Injury. Otolaryngol Head Neck Surg. 2023 Feb 9. doi: 10.1002/ohn.262. Epub ahead of print. PMID: 36758958.