WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130276
CAS#: 479422-22-5
Description: CDIBA is an inhibitor of cytosolic phospholipase A2 (cPLA(2)) and has been used to study the effects of cPLA(2) on tumor angiogenesis.
Hodoodo Cat#: H130276
Name: CDIBA
CAS#: 479422-22-5
Chemical Formula: C31H26ClNO3
Exact Mass: 495.16
Molecular Weight: 496.000
Elemental Analysis: C, 75.07; H, 5.28; Cl, 7.15; N, 2.82; O, 9.68
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Synonym: CDIBA; Cdiba
IUPAC/Chemical Name: 4-(2-(1-benzhydryl-5-chloro-2-methyl-1H-indol-3-yl)ethoxy)benzoic acid
InChi Key: WCJGWNYPOLQBKZ-UHFFFAOYSA-N
InChi Code: InChI=1S/C31H26ClNO3/c1-21-27(18-19-36-26-15-12-24(13-16-26)31(34)35)28-20-25(32)14-17-29(28)33(21)30(22-8-4-2-5-9-22)23-10-6-3-7-11-23/h2-17,20,30H,18-19H2,1H3,(H,34,35)
SMILES Code: O=C(O)C1=CC=C(OCCC2=C(C)N(C(C3=CC=CC=C3)C4=CC=CC=C4)C5=C2C=C(Cl)C=C5)C=C1
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 496.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Lee JH, Kim S, Jin MS, Kim YC. Discovery of substituted indole derivatives as allosteric inhibitors of m6 A-RNA methyltransferase, METTL3-14 complex. Drug Dev Res. 2022 May;83(3):783-799. doi: 10.1002/ddr.21910. Epub 2022 Jan 18. PMID: 35040501.
2. Linkous AG, Yazlovitskaya EM, Hallahan DE. Cytosolic phospholipase A2 and lysophospholipids in tumor angiogenesis. J Natl Cancer Inst. 2010 Sep 22;102(18):1398-412. doi: 10.1093/jnci/djq290. Epub 2010 Aug 20. PMID: 20729478; PMCID: PMC2943523.
3. Supinski GS, Alimov AP, Wang L, Song XH, Callahan LA. Calcium-dependent phospholipase A2 modulates infection-induced diaphragm dysfunction. Am J Physiol Lung Cell Mol Physiol. 2016 May 15;310(10):L975-84. doi: 10.1152/ajplung.00312.2015. Epub 2016 Mar 11. PMID: 26968769; PMCID: PMC4896095.
4. Zhou XL, Wei XJ, Li SP, Liu RN, Yu MX, Zhao Y. Interactions between Cytosolic Phospholipase A2 Activation and Mitochondrial Reactive Oxygen Species Production in the Development of Ventilator-Induced Diaphragm Dysfunction. Oxid Med Cell Longev. 2019 Apr 18;2019:2561929. doi: 10.1155/2019/2561929. PMID: 31178955; PMCID: PMC6501131.