WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130287
CAS#: N/A
Description: CQ80 is a PEPD/XPNPEP1 inhibitor that leads to the activation of CARD8 inflammasome.
Hodoodo Cat#: H130287
Name: CQ80
CAS#: N/A
Chemical Formula: C19H35N3O5
Exact Mass: 385.26
Molecular Weight: 385.510
Elemental Analysis: Chemical Formula: Exact Mass: Molecular Weight: Elemental Analysis: C, 59.20; H, 9.15; N, 10.90; O, 20.75
This product is not in stock, which may be available by custom synthesis.
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Synonym: CQ80; CQ 80; CQ-80
IUPAC/Chemical Name: methyl ((2S,3R)-3-amino-2-hydroxy-5-methylhexanoyl)-L-prolyl-L-leucinate
InChi Key: KIJPBYWZPRDUHB-UGUYLWEFSA-N
InChi Code: InChI=1S/C19H35N3O5/c1-11(2)9-13(20)16(23)18(25)22-8-6-7-15(22)17(24)21-14(10-12(3)4)19(26)27-5/h11-16,23H,6-10,20H2,1-5H3,(H,21,24)/t13-,14+,15+,16+/m1/s1
SMILES Code: CC(C)C[C@@H](C(OC)=O)NC([C@H]1N(C([C@@H](O)[C@H](N)CC(C)C)=O)CCC1)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 385.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Chen Q, Wang A, Covelli DJ, Bhattacharjee A, Wang Q, Orth-He EL, Rao SD, Huang HC, Ball DP, Hsiao JC, Bachovchin DA. Optimized M24B Aminopeptidase Inhibitors for CARD8 Inflammasome Activation. J Med Chem. 2023 Feb 23;66(4):2589-2607. doi: 10.1021/acs.jmedchem.2c01535. Epub 2023 Feb 1. PMID: 36724486.