WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130273
CAS#: N/A
Description: MOERAS115 is a CYP11B2 inhibitor (IC50 = 1.7 nM and selectivity of 16.5).
Hodoodo Cat#: H130273
Name: MOERAS115
CAS#: N/A
Chemical Formula: C17H13N3
Exact Mass: 259.11
Molecular Weight: 259.310
Elemental Analysis: C, 78.74; H, 5.05; N, 16.20
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Synonym: MOERAS115; MOERAS 115; MOERAS-115
IUPAC/Chemical Name: 4-((5-phenyl-1H-imidazol-1-yl)methyl)benzonitrile
InChi Key: HPKNNFRLCPHIRD-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H13N3/c18-10-14-6-8-15(9-7-14)12-20-13-19-11-17(20)16-4-2-1-3-5-16/h1-9,11,13H,12H2
SMILES Code: N#CC1=CC=C(CN2C(C3=CC=CC=C3)=CN=C2)C=C1
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 259.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Roumen L, Peeters JW, Emmen JM, Beugels IP, Custers EM, de Gooyer M, Plate R, Pieterse K, Hilbers PA, Smits JF, Vekemans JA, Leysen D, Ottenheijm HC, Janssen HM, Hermans JJ. Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2). J Med Chem. 2010 Feb 25;53(4):1712-25. doi: 10.1021/jm901356d. PMID: 20121113.