WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130297
CAS#: N/A
Description: CEU-818 is an antiproliferative agent against human breast carcinoma, specifically MCF-7 cells, cancer cells expressing CYP1A1.
Hodoodo Cat#: H130297
Name: CEU-818
CAS#: N/A
Chemical Formula: C22H28N2O7S
Exact Mass: 464.16
Molecular Weight: 464.530
Elemental Analysis: C, 56.88; H, 6.08; N, 6.03; O, 24.11; S, 6.90
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Synonym: CEU-818; CEU818; CEU 818
IUPAC/Chemical Name: 3,4,5-trimethoxyphenyl 4-(3-butyl-2-oxoimidazolidin-1-yl)benzenesulfonate
InChi Key: XUEJZYKHBJYFNX-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H28N2O7S/c1-5-6-11-23-12-13-24(22(23)25)16-7-9-18(10-8-16)32(26,27)31-17-14-19(28-2)21(30-4)20(15-17)29-3/h7-10,14-15H,5-6,11-13H2,1-4H3
SMILES Code: O=S(C1=CC=C(N2CCN(CCCC)C2=O)C=C1)(OC3=CC(OC)=C(OC)C(OC)=C3)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 464.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1. Zarifi Khosroshahi M, Corin Chavez Alvarez A, Gagné-Boulet M, C-Gaudreault R, Gobeil S, Fortin S. Evaluation of the time-dependent antiproliferative activity and liver microsome stability of 3 phenyl 4-(2-oxo-3-alkylimidazolidin-1-yl)benzenesulfonates as promising CYP1A1-dependent antimicrotubule prodrugs. J Pharm Pharmacol. 2020 Feb;72(2):249-258. doi: 10.1111/jphp.13198. Epub 2019 Nov 14. PMID: 31729035.
2. Chavez Alvarez AC, Bouzriba C, Moreau E, Auzeloux P, Besse S, Ouellette V, Zarifi Khosroshahi M, Côté MF, Pilote S, Miot-Noirault E, Chezal JM, Simard C, C-Gaudreault R, Fortin S. Homologation of the Alkyl Side Chain of Antimitotic Phenyl 4-(2-Oxo-3-alkylimidazolidin-1-yl)benzenesulfonate Prodrugs Selectively Targeting CYP1A1-Expressing Breast Cancers Improves Their Stability in Rodent Liver Microsomes. J Med Chem. 2023 Feb 23;66(4):2477-2497. doi: 10.1021/acs.jmedchem.2c01268. Epub 2023 Feb 13. PMID: 36780426.
