WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H122946
CAS#: 73439-19-7
Description: COH-SR4 is a Mitochondrial Uncoupler
Hodoodo Cat#: H122946
Name: COH-SR4
CAS#: 73439-19-7
Chemical Formula: C13H8Cl4N2O
Exact Mass: 347.94
Molecular Weight: 350.020
Elemental Analysis: C, 44.61; H, 2.30; Cl, 40.51; N, 8.00; O, 4.57
This product is not in stock, which may be available by custom synthesis.
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Synonym: COH-SR4; COHSR4; COH SR4
IUPAC/Chemical Name: 1,3-bis(3,5-dichlorophenyl)urea
InChi Key: VKVJIWVUYNTBEZ-UHFFFAOYSA-N
InChi Code: InChI=1S/C13H8Cl4N2O/c14-7-1-8(15)4-11(3-7)18-13(20)19-12-5-9(16)2-10(17)6-12/h1-6H,(H2,18,19,20)
SMILES Code: O=C(NC1=CC(Cl)=CC(Cl)=C1)NC2=CC(Cl)=CC(Cl)=C2
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 350.02 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Figarola JL, Rahbar S. Small‑molecule COH-SR4 inhibits adipocyte
differentiation via AMPK activation. Int J Mol Med. 2013 May;31(5):1166-76. doi:
10.3892/ijmm.2013.1313. Epub 2013 Mar 21. PMID: 23525347.
2: Figarola JL, Singhal P, Rahbar S, Gugiu BG, Awasthi S, Singhal SS. COH-SR4
reduces body weight, improves glycemic control and prevents hepatic steatosis in
high fat diet-induced obese mice. PLoS One. 2013 Dec 20;8(12):e83801. doi:
10.1371/journal.pone.0083801. PMID: 24376752; PMCID: PMC3869817.
3: Singhal SS, Figarola J, Singhal J, Leake K, Nagaprashantha L, Lincoln C,
Gabriel Gugiu B, Horne D, Jove R, Awasthi S, Rahbar S.
1,3-Bis(3,5-dichlorophenyl) urea compound 'COH-SR4' inhibits proliferation and
activates apoptosis in melanoma. Biochem Pharmacol. 2012 Dec 1;84(11):1419-27.
doi: 10.1016/j.bcp.2012.08.020. Epub 2012 Aug 28. PMID: 22959823; PMCID:
PMC3747778.
4: Singhal SS, Figarola J, Singhal J, Nagaprashantha L, Berz D, Rahbar S,
Awasthi S. Novel compound 1,3-bis (3,5-dichlorophenyl) urea inhibits lung cancer
progression. Biochem Pharmacol. 2013 Dec 15;86(12):1664-72. doi:
10.1016/j.bcp.2013.09.022. Epub 2013 Oct 4. PMID: 24099794; PMCID: PMC4186798.
5: Limbach KE, Wen W, Xing Q, Yan J, Yim JH. Baicalein activates 5' adenosine
monophosphate-activated protein kinase, inhibits the mammalian target of
rapamycin, and exhibits antiproliferative effects in pancreatic neuroendocrine
tumors in vitro and in vivo. Surgery. 2023 Jan;173(1):12-18. doi:
10.1016/j.surg.2022.07.030. Epub 2022 Oct 4. PMID: 36207198.
