WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H122948
CAS#: N/A
Description: LY3127760 is a EP4 antagonist.
Hodoodo Cat#: H122948
Name: LY3127760
CAS#: N/A
Chemical Formula: C21H25N3O4
Exact Mass: 383.18
Molecular Weight: 383.450
Elemental Analysis: C, 65.78; H, 6.57; N, 10.96; O, 16.69
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Synonym: LY3127760; LY 3127760; LY-3127760
IUPAC/Chemical Name: 4-(6-(4-hydroxypiperidin-1-yl)-3-methylpicolinamido)-3,5-dimethylbenzoic acid
InChi Key: WOJKYHBOHSQZDW-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H25N3O4/c1-12-4-5-17(24-8-6-16(25)7-9-24)22-19(12)20(26)23-18-13(2)10-15(21(27)28)11-14(18)3/h4-5,10-11,16,25H,6-9H2,1-3H3,(H,23,26)(H,27,28)
SMILES Code: CC1=C(NC(C2=C(C=CC(N3CCC(O)CC3)=N2)C)=O)C(C)=CC(C(O)=O)=C1
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 383.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Jin Y, Smith C, Hu L, Coutant DE, Whitehurst K, Phipps K, McNearney TA, Yang X, Ackermann B, Pottanat T, Landschulz W. LY3127760, a Selective Prostaglandin E4 (EP4) Receptor Antagonist, and Celecoxib: A Comparison of Pharmacological Profiles. Clin Transl Sci. 2018 Jan;11(1):46-53. doi: 10.1111/cts.12497. Epub 2017 Aug 30. PMID: 28857461; PMCID: PMC5759725.