WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130296
CAS#: 130775-79-0
Description: MS-153, which activates the glutamate transporter, has been shown to reduce the conditioned rewarding effect of morphine, methamphetamine, and cocaine without negatively affecting acute locomotor responses in mice.
Hodoodo Cat#: H130296
Name: MS-153
CAS#: 130775-79-0
Chemical Formula: C10H11N3O
Exact Mass: 189.09
Molecular Weight: 189.220
Elemental Analysis: C, 63.48; H, 5.86; N, 22.21; O, 8.46
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Synonym: MS-153; MS153; MS 153
IUPAC/Chemical Name: (R)-(5-methyl-4,5-dihydro-1H-pyrazol-1-yl)(pyridin-3-yl)methanone
InChi Key: KKMMIKKVFRCZBO-MRVPVSSYSA-N
InChi Code: InChI=1S/C10H11N3O/c1-8-4-6-12-13(8)10(14)9-3-2-5-11-7-9/h2-3,5-8H,4H2,1H3/t8-/m1/s1
SMILES Code: O=C(N1N=CC[C@H]1C)C2=CC=CN=C2
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 189.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Nakagawa T, Fujio M, Ozawa T, Minami M, Satoh M. Effect of MS-153, a glutamate transporter activator, on the conditioned rewarding effects of morphine, methamphetamine and cocaine in mice. Behav Brain Res. 2005 Jan 30;156(2):233-9. doi: 10.1016/j.bbr.2004.05.029. PMID: 15582109.