WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H122980
CAS#: 2440087-54-5
Description: ERX-41 is an inducer of endoplasmic reticulum (ER) stress.
Hodoodo Cat#: H122980
Name: ERX-41
CAS#: 2440087-54-5
Chemical Formula: C38H48N4O9
Exact Mass: 704.34
Molecular Weight: 704.820
Elemental Analysis: C, 64.76; H, 6.86; N, 7.95; O, 20.43
Synonym: ERX-41; ERX41; ERX 41
IUPAC/Chemical Name: 3-(2-hydroxyethoxy)-N-(2-isobutoxy-4-((2-isobutoxy-4-(((1r,4r)-4-methylcyclohexyl)carbamoyl)phenyl)carbamoyl)phenyl)-4-nitrobenzamide
InChi Key: QOYORXKDWMJNHD-UAHYGDRYSA-N
InChi Code: InChI=1S/C38H48N4O9/c1-23(2)21-50-33-18-26(36(44)39-29-11-6-25(5)7-12-29)8-13-30(33)40-37(45)27-9-14-31(34(19-27)51-22-24(3)4)41-38(46)28-10-15-32(42(47)48)35(20-28)49-17-16-43/h8-10,13-15,18-20,23-25,29,43H,6-7,11-12,16-17,21-22H2,1-5H3,(H,39,44)(H,40,45)(H,41,46)/t25-,29-
SMILES Code: OCCOC1=C([N+]([O-])=O)C=CC(C(NC2=CC=C(C(NC3=CC=C(C(N[C@@H]4CC[C@@H](C)CC4)=O)C=C3OCC(C)C)=O)C=C2OCC(C)C)=O)=C1
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 704.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Liu X, Viswanadhapalli S, Kumar S, Lee TK, Moore A, Ma S, Chen L, Hsieh M, Li M, Sareddy GR, Parra K, Blatt EB, Reese TC, Zhao Y, Chang A, Yan H, Xu Z, Pratap UP, Liu Z, Roggero CM, Tan Z, Weintraub ST, Peng Y, Tekmal RR, Arteaga CL, Lippincott-Schwartz J, Vadlamudi RK, Ahn JM, Raj GV. Targeting LIPA independent of its lipase activity is a therapeutic strategy in solid tumors via induction of endoplasmic reticulum stress. Nat Cancer. 2022 Jul;3(7):866-884. doi: 10.1038/s43018-022-00389-8. Epub 2022 Jun 2. PMID: 35654861; PMCID: PMC9325671.