WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130309
CAS#: N/A
Description: S2-Puro is a prodrug of puromycin and is activated by thiols.
Hodoodo Cat#: H130309
Name: S2-Puro
CAS#: N/A
Chemical Formula: C27H37N7O8S2
Exact Mass: 651.21
Molecular Weight: 651.750
Elemental Analysis: C, 49.76; H, 5.72; N, 15.04; O, 19.64; S, 9.84
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Synonym: S2-Puro; S2 Puro
IUPAC/Chemical Name: 2-((2-hydroxyethyl)disulfanyl)ethyl ((S)-1-(((2S,3S,4R,5R)-5-(6-(dimethylamino)-9H-purin-9-yl)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl)amino)-3-(4-methoxyphenyl)-1-oxopropan-2-yl)carbamate
InChi Key: RKSDZYIRVJGIGQ-HOEDKODCSA-N
InChi Code: InChI=1S/C27H37N7O8S2/c1-33(2)23-21-24(29-14-28-23)34(15-30-21)26-22(37)20(19(13-36)42-26)32-25(38)18(12-16-4-6-17(40-3)7-5-16)31-27(39)41-9-11-44-43-10-8-35/h4-7,14-15,18-20,22,26,35-37H,8-13H2,1-3H3,(H,31,39)(H,32,38)/t18-,19+,20+,22+,26+/m0/s1
SMILES Code: O=C(OCCSSCCO)N[C@@H](CC1=CC=C(OC)C=C1)C(N[C@@H]2[C@@H](CO)O[C@@H](N3C=NC4=C(N(C)C)N=CN=C34)[C@@H]2O)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 651.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Chang B, Xu Q, Guo H, Zhong M, Shen R, Zhao L, Zhao J, Ma T, Chu Y, Zhang J, Fang J. Puromycin Prodrug Activation by Thioredoxin Reductase Overcomes Its Promiscuous Cytotoxicity. J Med Chem. 2023 Mar 9;66(5):3250-3261. doi: 10.1021/acs.jmedchem.2c01509. Epub 2023 Mar 1. PMID: 36855911.