WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H122981
CAS#: 6379-56-2
Description: Hygromycin A, also known as Homomycin A and Hygromycin A, is an antibiotic originally isolated from S. hygroscopicus. It was thought that the strongest antibiotic activity of totomycin was against Staphylococcus haemolyticus, in which growth was inhibited by concentrations of 2 µg/mL. Other gram-positive and gram-negative sensitive to totomycin are inhibited by concentrations from 16 to 31 µg/mL. In 2021 it was reported that Hygromycin A is very effective against spirochetes and can be used to eliminate the spirochete that causes Lyme disease. Bait laced with hygromycin A could be used to eliminate Lyme disease in the wild.
Hodoodo Cat#: H122981
Name: Hygromycin A
CAS#: 6379-56-2
Chemical Formula: C23H29NO12
Exact Mass: 511.17
Molecular Weight: 511.480
Elemental Analysis: C, 54.01; H, 5.72; N, 2.74; O, 37.54
Synonym: Homomycin; Hygromycin; (-)-Hygromycin A; 1703-18B; Antibiotic WS 1627B; Hygromycin A; Totomycin
IUPAC/Chemical Name: (E)-3-(4-(((2S,3S,4S,5S)-5-acetyl-3,4-dihydroxytetrahydrofuran-2-yl)oxy)-3-hydroxyphenyl)-2-methyl-N-((3aS,4R,5R,6S,7R,7aR)-4,6,7-trihydroxyhexahydrobenzo[d][1,3]dioxol-5-yl)acrylamide
InChi Key: YQYJSBFKSSDGFO-IIHALWDASA-N
InChi Code: InChI=1S/C23H29NO12/c1-8(22(32)24-13-14(27)16(29)21-20(15(13)28)33-7-34-21)5-10-3-4-12(11(26)6-10)35-23-18(31)17(30)19(36-23)9(2)25/h3-6,13-21,23,26-31H,7H2,1-2H3,(H,24,32)/b8-5+/t13-,14+,15-,16-,17+,18+,19-,20+,21-,23-/m1/s1
SMILES Code: O[C@H]1[C@]2([C@@]([H])([C@H](O)[C@@H](O)[C@H]1NC(/C(C)=C/C3=CC(O)=C(O[C@H]4[C@H]([C@@H]([C@H](O4)C(C)=O)O)O)C=C3)=O)OCO2)[H]
Appearance: To be determined
Purity: >95% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 511.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
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