WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130320
CAS#: 2298391-60-1
Description: ENPP1 inhibitor 32 is an ENPP1 inhibitor with anti-tumor activity.
Hodoodo Cat#: H130320
Name: ENPP1 inhibitor 32
CAS#: 2298391-60-1
Chemical Formula: C16H22N3O4P
Exact Mass: 351.13
Molecular Weight: 351.340
Elemental Analysis: C, 54.70; H, 6.31; N, 11.96; O, 18.21; P, 8.82
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Synonym: ENPP1 inhibitor 32
IUPAC/Chemical Name: (2-(1-(8-methoxyquinazolin-4-yl)piperidin-4-yl)ethyl)phosphonic acid
InChi Key: IXXUGBPAQOKGTM-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H22N3O4P/c1-23-14-4-2-3-13-15(14)17-11-18-16(13)19-8-5-12(6-9-19)7-10-24(20,21)22/h2-4,11-12H,5-10H2,1H3,(H2,20,21,22)
SMILES Code: COC1=CC=CC2=C(N3CCC(CCP(O)(O)=O)CC3)N=CN=C12
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 351.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Carozza JA, Brown JA, Böhnert V, Fernandez D, AlSaif Y, Mardjuki RE, Smith M, Li L. Structure-Aided Development of Small-Molecule Inhibitors of ENPP1, the Extracellular Phosphodiesterase of the Immunotransmitter cGAMP. Cell Chem Biol. 2020 Nov 19;27(11):1347-1358.e5. doi: 10.1016/j.chembiol.2020.07.007. Epub 2020 Jul 28. PMID: 32726585; PMCID: PMC7680421.