WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130317
CAS#: 2426628-52-4
Description: JH-XIV-68-3 is a Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A/ B (DYRK1A/B) inhibitor.
Hodoodo Cat#: H130317
Name: JH-XIV-68-3
CAS#: 2426628-52-4
Chemical Formula: C21H17F3N8O
Exact Mass: 454.15
Molecular Weight: 454.420
Elemental Analysis: C, 55.51; H, 3.77; F, 12.54; N, 24.66; O, 3.52
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Synonym: JH-XIV-68-3; JH XIV 68 3; JH XIV-68-3
IUPAC/Chemical Name: 10,13-Dimethyl-9-oxo-3-(trifluoromethyl)-4,5,10,12,13,18,20-heptazapentacyclo[14.5.2.12,5.011,15.019,22]tetracosa-1(21),2(24),3,11,14,16(23),17,19(22)-octaene-14-carbonitrile
InChi Key: OUWNBPQKRZSLKD-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H17F3N8O/c1-30-16(33)4-3-5-32-10-14(18(28-32)21(22,23)24)13-9-27-19-12(13)6-11(8-26-19)17-15(7-25)31(2)29-20(17)30/h6,8-10H,3-5H2,1-2H3,(H,26,27)
SMILES Code: N#CC1=C2C3=CC(C(C4=CN(CCCC(N(C)C2=NN1C)=O)N=C4C(F)(F)F)=CN5)=C5N=C3
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 454.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Powell CE, Hatcher JM, Jiang J, Vatsan PS, Che J, Gray NS. Selective Macrocyclic Inhibitors of DYRK1A/B. ACS Med Chem Lett. 2022 Mar 8;13(4):577-585. doi: 10.1021/acsmedchemlett.1c00630. PMID: 35450378; PMCID: PMC9014431.