WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130316
CAS#: N/A
Description: KS40008 is an inhibitor of the dual-specificity tyrosine phosphorylation-regulated kinase family (DYRK), specifically 1A/B, promoting anti-proliferative activity in colorectal cell lines. KS40008 has been found to promote mitochondrial dysfunction and endoplasmic reticulum stress, leading to the autophagic death of cancer cells.
Hodoodo Cat#: H130316
Name: KS40008
CAS#: N/A
Chemical Formula: C18H13N3O3
Exact Mass: 319.10
Molecular Weight: 319.320
Elemental Analysis: C, 67.71; H, 4.10; N, 13.16; O, 15.03
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Synonym: KS40008; KS 40008; KS-40008
IUPAC/Chemical Name: 4-(3-(4-hydroxyphenyl)-2H-pyrazolo[3,4-b]pyridin-5-yl)benzene-1,2-diol
InChi Key: QSRKFVZHMMKLIL-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H13N3O3/c22-13-4-1-10(2-5-13)17-14-7-12(9-19-18(14)21-20-17)11-3-6-15(23)16(24)8-11/h1-9,22-24H,(H,19,20,21)
SMILES Code: OC1=CC=C(C2=CC3=C(C4=CC=C(O)C=C4)NN=C3N=C2)C=C1O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 319.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Hwang J, Park A, Kim C, Yu D, Byun H, Ku M, Yang J, Kim TI, Jeong KS, Kim KY, Lee H, Shin SJ. Suppression of DYRK1A/B Drives Endoplasmic Reticulum Stress-mediated Autophagic Cell Death Through Metabolic Reprogramming in Colorectal Cancer Cells. Anticancer Res. 2022 Jan;42(1):589-598. doi: 10.21873/anticanres.15516. PMID: 34969768.