NBI-12i

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H130314

CAS#: N/A

Description: NBI-12i is a melanocortin-4 receptor (MC4-R) antagonist that is able to enter the nervous system and was found to reduce uremia-associated cachexia in mice.

Chemical Structure

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NBI-12i
CAS# N/A
Instruction

Theoretical Analysis

Hodoodo Cat#: H130314
Name: NBI-12i
CAS#: N/A
Chemical Formula: C25H36Cl2N4O4
Exact Mass: 526.21
Molecular Weight: 527.490
Elemental Analysis: C, 56.93; H, 6.88; Cl, 13.44; N, 10.62; O, 12.13

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: NBI-12i; NBI12i; NBI 12i

IUPAC/Chemical Name: ethyl (1S,2S)-2-(4-((R)-2-(3-aminopropanamido)-3-(2,4-dichlorophenyl)propanoyl)piperazin-1-yl)cyclohexane-1-carboxylate

InChi Key: BHZMEZUGBXLPOY-NNWRFLSQSA-N

InChi Code: InChI=1S/C25H36Cl2N4O4/c1-2-35-25(34)19-5-3-4-6-22(19)30-11-13-31(14-12-30)24(33)21(29-23(32)9-10-28)15-17-7-8-18(26)16-20(17)27/h7-8,16,19,21-22H,2-6,9-15,28H2,1H3,(H,29,32)/t19-,21+,22-/m0/s1

SMILES Code: O=C([C@@H]1[C@@H](N2CCN(C([C@H](NC(CCN)=O)CC3=CC=C(Cl)C=C3Cl)=O)CC2)CCCC1)OCC

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 527.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Cheung WW, Kuo HJ, Markison S, Chen C, Foster AC, Marks DL, Mak RH. Peripheral administration of the melanocortin-4 receptor antagonist NBI-12i ameliorates uremia-associated cachexia in mice. J Am Soc Nephrol. 2007 Sep;18(9):2517-24. doi: 10.1681/ASN.2006091024. Epub 2007 Aug 8. PMID: 17687077.

2. Markison S, Foster AC, Chen C, Brookhart GB, Hesse A, Hoare SR, Fleck BA, Brown BT, Marks DL. The regulation of feeding and metabolic rate and the prevention of murine cancer cachexia with a small-molecule melanocortin-4 receptor antagonist. Endocrinology. 2005 Jun;146(6):2766-73. doi: 10.1210/en.2005-0142. Epub 2005 Mar 17. PMID: 15774557.