DBCO-maleimide
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Hodoodo CAT#: H130324

CAS#: N/A

Description: DBCO-maleimide is used to incorporate cyclooctyne moiety into compounds containing thiol for the creation of compounds including protein-peptide conjugates, antibody-enzyme or antibody-drug conjugates, protein or peptide-oligonucleotide conjugates, as well as surface modifications.

Chemical Structure

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DBCO-maleimide
CAS# N/A
Instruction

Theoretical Analysis

Hodoodo Cat#: H130324
Name: DBCO-maleimide
CAS#: N/A
Chemical Formula: C25H21N3O4
Exact Mass: 427.15
Molecular Weight: 427.460
Elemental Analysis: C, 70.25; H, 4.95; N, 9.83; O, 14.97

Price and Availability

Size Price Availability Quantity
1mg USD 290 2 Weeks
5mg USD 560 2 Weeks
50mg USD 1050 2 Weeks
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Synonym: DBCO-maleimide; Dibenzocyclooctyne-maleimide

IUPAC/Chemical Name: N/A

InChi Key: NHFQNAGPXIVKND-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H21N3O4/c29-22(14-16-27-23(30)11-12-24(27)31)26-15-13-25(32)28-17-20-7-2-1-5-18(20)9-10-19-6-3-4-8-21(19)28/h1-8,11-12H,13-17H2,(H,26,29)

SMILES Code: O=C(C=CC1=O)N1CCC(NCCC(N2CC3=C(C#CC4=C2C=CC=C4)C=CC=C3)=O)=O

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 427.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Kiseleva RY, Glassman PG, LeForte KM, Walsh LR, Villa CH, Shuvaev VV, Myerson JW, Aprelev PA, Marcos-Contreras OA, Muzykantov VR, Greineder CF. Bivalent engagement of endothelial surface antigens is critical to prolonged surface targeting and protein delivery in vivo. FASEB J. 2020 Sep;34(9):11577-11593. doi: 10.1096/fj.201902515RR. Epub 2020 Aug 1. PMID: 32738178; PMCID: PMC8444999.