WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H123016
CAS#: N/A
Description: BGB-8035 is a Highly Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase (BTK IC50 = 1.1 nM)for B‑Cell Malignancies and Autoimmune Diseases. BGB-8035 showed an excellent pharmacokinetic profile as well as demonstrated efficacy studies in oncology and autoimmune disease models.
Hodoodo Cat#: H123016
Name: BGB-8035
CAS#: N/A
Chemical Formula: C24H31N5O5
Exact Mass: 469.23
Molecular Weight: 469.540
Elemental Analysis: C, 61.39; H, 6.65; N, 14.92; O, 17.04
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Synonym: BGB-8035; BGB8035; BGB 8035
IUPAC/Chemical Name: (S)-7-(1-acryloylpiperidin-4-yl)-2-(3,4,5-trimethoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide
InChi Key: OOQZZMMAJFGPIS-INIZCTEOSA-N
InChi Code: InChI=1S/C24H31N5O5/c1-5-19(30)28-10-7-14(8-11-28)16-6-9-26-24-20(23(25)31)21(27-29(16)24)15-12-17(32-2)22(34-4)18(13-15)33-3/h5,12-14,16,26H,1,6-11H2,2-4H3,(H2,25,31)/t16-/m0/s1
SMILES Code: C=CC(N(CC1)CCC1[C@@H]2CCNC3=C(C(N)=O)C(C4=CC(OC)=C(OC)C(OC)=C4)=NN32)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 469.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Guo Y, Hu N, Liu Y, Zhang W, Yu D, Shi G, Zhang B, Yin L, Wei M, Yuan X, Luo L, Wang F, Song X, Xin L, Wei Q, Li Y, Guo Y, Chen S, Zhang T, Zhang S, Zhou X, Zhang C, Su D, Liu J, Cheng Z, Zhang J, Xing H, Sun H, Li X, Zhao Y, He M, Wu Y, Guo Y, Sun X, Tian A, Zhou C, Young S, Liu X, Wang L, Wang Z. Discovery of BGB-8035, a Highly Selective Covalent Inhibitor of Bruton's Tyrosine Kinase for B-Cell Malignancies and Autoimmune Diseases. J Med Chem. 2023 Mar 13. doi: 10.1021/acs.jmedchem.2c01938. Epub ahead of print. PMID: 36912866.