WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H123021
CAS#: N/A
Description: ZZ151 is a Potent, Cooperative, and Selective SOS1 PROTAC with In Vivo Antitumor Efficacy in KRAS-Mutant Cancers. ZZ151 quickly, specifically, and effectively induced SOS1 degradation; displayed potent antiproliferation activities against a broad panel of KRAS mutant-driven cancer cells; and showed superior anticancer activities in the KRASG12D- and G12V-mutant xenografts in mice. ZZ151 is a promising lead for developing new chemotherapies targeting KRAS mutants.
Hodoodo Cat#: H123021
Name: ZZ151
CAS#: N/A
Chemical Formula: C54H68F3N9O6S
Exact Mass: 1,027.50
Molecular Weight: 1,028.250
Elemental Analysis: C, 63.08; H, 6.67; F, 5.54; N, 12.26; O, 9.34; S, 3.12
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Synonym: ZZ151; ZZ 151; ZZ-151
IUPAC/Chemical Name: (2S,4R)-1-((S)-2-(7-(4-(4-(((R)-1-(3-amino-5-(trifluoromethyl)phenyl)ethyl)amino)-7-methoxy-2-methylquinazolin-6-yl)piperidin-1-yl)-7-oxoheptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
InChi Key: IIUMLDLNPGCAPX-GGCSJQPYSA-N
InChi Code: InChI=1S/C54H68F3N9O6S/c1-30(34-14-16-36(17-15-34)48-32(3)59-29-73-48)61-51(70)44-25-40(67)28-66(44)52(71)49(53(5,6)7)64-46(68)12-10-9-11-13-47(69)65-20-18-35(19-21-65)41-26-42-43(27-45(41)72-8)62-33(4)63-50(42)60-31(2)37-22-38(54(55,56)57)24-39(58)23-37/h14-17,22-24,26-27,29-31,35,40,44,49,67H,9-13,18-21,25,28,58H2,1-8H3,(H,61,70)(H,64,68)(H,60,62,63)/t30-,31+,40+,44-,49+/m0/s1
SMILES Code: O=C([C@H]1N(C([C@@H](NC(CCCCCC(N2CCC(C3=CC4=C(N[C@@H](C5=CC(C(F)(F)F)=CC(N)=C5)C)N=C(C)N=C4C=C3OC)CC2)=O)=O)C(C)(C)C)=O)C[C@H](O)C1)N[C@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 1,028.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
Zhou Z, Zhou G, Zhou C, Fan Z, Cui R, Li Y, Li R, Gu Y, Li H, Ge Z, Cai X, Jiang B, Wang D, Zheng M, Xu T, Zhang S. Discovery of a Potent, Cooperative, and Selective SOS1 PROTAC ZZ151 with In Vivo Antitumor Efficacy in KRAS-Mutant Cancers. J Med Chem. 2023 Mar 23;66(6):4197-4214. doi: 10.1021/acs.jmedchem.3c00075. Epub 2023 Mar 10. PMID: 36897932.
