WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H123026
CAS#: 872717-97-0
Description: KISS1 305 is a potent Kisspeptin1 receptor agonist.
Hodoodo Cat#: H123026
Name: KISS1 305
CAS#: 872717-97-0
Chemical Formula: C56H76N16O12
Exact Mass: 1,164.58
Molecular Weight: 1,165.320
Elemental Analysis: C, 57.72; H, 6.57; N, 19.23; O, 16.48
Synonym: KISS1 305; KISS1-305; CHEMBL3086284; Tp-005; HY-P2191; BDBM50442961
IUPAC/Chemical Name: (S)-N1-((8S,11S,17S,20S)-8-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)carbamoyl)-17-benzyl-21-hydroxy-3-imino-11-isobutyl-10,13,16,19-tetraoxo-2,4,9,12,14,15,18-heptaazahenicosan-20-yl)-2-((R)-2-((R)-2-amino-3-(4-hydroxyphenyl)propanamido)-3-(pyridin-4-yl)propanamido)succinamide
InChi Key: YSVWFFNZZGLLAI-XNTOLAJGSA-N
InChi Code: InChI=1S/C56H76N16O12/c1-32(2)25-41(50(79)64-39(15-10-22-63-55(60)61-3)49(78)65-40(47(59)76)27-33-11-6-4-7-12-33)70-56(84)72-71-54(83)43(28-34-13-8-5-9-14-34)67-53(82)45(31-73)69-52(81)44(30-46(58)75)68-51(80)42(29-36-20-23-62-24-21-36)66-48(77)38(57)26-35-16-18-37(74)19-17-35/h4-9,11-14,16-21,23-24,32,38-45,73-74H,10,15,22,25-31,57H2,1-3H3,(H2,58,75)(H2,59,76)(H,64,79)(H,65,78)(H,66,77)(H,67,82)(H,68,80)(H,69,81)(H,71,83)(H3,60,61,63)(H2,70,72,84)/t38-,39+,40+,41+,42-,43+,44+,45+/m1/s1
SMILES Code: O=C(N[C@@H](CCCNC(NC)=N)C(N[C@@H](CC1=CC=CC=C1)C(N)=O)=O)[C@H](CC(C)C)NC(NNC([C@H](CC2=CC=CC=C2)NC([C@H](CO)NC([C@H](CC(N)=O)NC([C@H](NC([C@@H](CC3=CC=C(C=C3)O)N)=O)CC4=CC=NC=C4)=O)=O)=O)=O)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 1,165.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Matsui H, Tanaka A, Yokoyama K, Takatsu Y, Ishikawa K, Asami T, Nishizawa N,
Suzuki A, Kumano S, Terada M, Kusaka M, Kitada C, Ohtaki T. Chronic
administration of the metastin/kisspeptin analog KISS1-305 or the
investigational agent TAK-448 suppresses hypothalamic pituitary gonadal function
and depletes plasma testosterone in adult male rats. Endocrinology. 2012
Nov;153(11):5297-308. doi: 10.1210/en.2012-1388. Epub 2012 Oct 1. PMID:
23027808.