WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H123051
CAS#: 939681-36-4
Description: G5-7 is an orally active and allosteric JAK2 inhibitor
Hodoodo Cat#: H123051
Name: G5-7
CAS#: 939681-36-4
Chemical Formula: C24H23F2NO3
Exact Mass: 411.16
Molecular Weight: 411.450
Elemental Analysis: C, 70.06; H, 5.63; F, 9.23; N, 3.40; O, 11.67
Synonym: G5-7; G57; G-5-7; G5 7; G-5 7; ert-Butyl 3,5-bis(2-fluorobenzylidene)-4-oxopiperidine-1-carboxylate; 939681-36-4; starbld0009706
IUPAC/Chemical Name: tert-butyl 3,5-bis((Z)-2-fluorobenzylidene)-4-oxopiperidine-1-carboxylate
InChi Key: MCSPIRBNMDODQP-BKHHGCLFSA-N
InChi Code: InChI=1S/C24H23F2NO3/c1-24(2,3)30-23(29)27-14-18(12-16-8-4-6-10-20(16)25)22(28)19(15-27)13-17-9-5-7-11-21(17)26/h4-13H,14-15H2,1-3H3/b18-12-,19-13-
SMILES Code: O=C(N1C/C(C(/C(C1)=C\C2=CC=CC=C2F)=O)=C/C3=CC=CC=C3F)OC(C)(C)C
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 411.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Paniagua R, García-López E, Ávila-Díaz M, Ventura MD, Orihuela O, Prado-Uribe
MD, Gallardo-Montoya JM, Lindholm B. Sex Modulates Cardiovascular Effects of
Icodextrin-Based Peritoneal Dialysis Solutions. Front Physiol. 2022 May
23;13:911072. doi: 10.3389/fphys.2022.911072. PMID: 35677090; PMCID: PMC9168216.
2: He K, Qi Q, Chan CB, Xiao G, Liu X, Tucker-Burden C, Wang L, Mao H, Lu X,
McDonald FE, Luo H, Fan QW, Weiss WA, Sun SY, Brat DJ, Ye K. Blockade of glioma
proliferation through allosteric inhibition of JAK2. Sci Signal. 2013 Jul
9;6(283):ra55. doi: 10.1126/scisignal.2003900. PMID: 23838182; PMCID:
PMC4772155.