WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130341
CAS#: 1609659-01-9
Description: TCO-PEG3-maleimide is a valuable agent for click chemistry applications, reacting with 1; 2; 4; 5-tetrazines without the need for a catalyst. The PEG spacer increases water solubility, decreases aggregation, and increases space for the thiol being modified with respect to the reactive alkene.
Hodoodo Cat#: H130341
Name: TCO-PEG3-maleimide
CAS#: 1609659-01-9
Chemical Formula: C26H41N3O8
Exact Mass: 523.29
Molecular Weight: 523.630
Elemental Analysis: C, 59.64; H, 7.89; N, 8.02; O, 24.44
Synonym: TCO-PEG3-maleimide; trans-Cyclooctene-maleimide
IUPAC/Chemical Name: (E)-cyclooct-4-en-1-yl (17-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-15-oxo-4,7,10-trioxa-14-azaheptadecyl)carbamate
InChi Key: BJZRPWAVCDJCTC-OWOJBTEDSA-N
InChi Code: InChI=1S/C26H41N3O8/c30-23(12-15-29-24(31)10-11-25(29)32)27-13-6-16-34-18-20-36-21-19-35-17-7-14-28-26(33)37-22-8-4-2-1-3-5-9-22/h1-2,10-11,22H,3-9,12-21H2,(H,27,30)(H,28,33)/b2-1+
SMILES Code: O=C(OC1CCC/C=C/CC1)NCCCOCCOCCOCCCNC(CCN2C(C=CC2=O)=O)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 523.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Allo B, Lou X, Bouzekri A, Ornatsky O. Clickable and High-Sensitivity Metal-Containing Tags for Mass Cytometry. Bioconjug Chem. 2018 Jun 20;29(6):2028-2038. doi: 10.1021/acs.bioconjchem.8b00239. Epub 2018 May 17. PMID: 29733585.
2. Platzer R, Rossboth BK, Schneider MC, Sevcsik E, Baumgart F, Stockinger H, Schütz GJ, Huppa JB, Brameshuber M. Unscrambling fluorophore blinking for comprehensive cluster detection via photoactivated localization microscopy. Nat Commun. 2020 Oct 5;11(1):4993. doi: 10.1038/s41467-020-18726-9. PMID: 33020470; PMCID: PMC7536177.