Wee1-IN-5
featured

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H123053

CAS#: 2243882-74-6

Description: WEE1-IN-5 (Debio 0123) is a potent Wee1 inhibitor that inhibits phospho-CDC2 and abrogates the G2 check point.

Chemical Structure

img
Wee1-IN-5
CAS# 2243882-74-6
Instruction

Theoretical Analysis

Hodoodo Cat#: H123053
Name: Wee1-IN-5
CAS#: 2243882-74-6
Chemical Formula: C26H28Cl2N6O
Exact Mass: 510.17
Molecular Weight: 511.450
Elemental Analysis: C, 61.06; H, 5.52; Cl, 13.86; N, 16.43; O, 3.13

Price and Availability

Size Price Availability Quantity
5mg USD 650 2 Weeks
25mg USD 1550 2 Weeks
Bulk inquiry

Synonym: Wee1-IN-5; Debio 0123; 2243882-74-6; SCHEMBL23298351; EX-A5145; HY-147054;

IUPAC/Chemical Name: 3-(2,6-dichlorophenyl)-1-methyl-7-((3-methyl-4-(1-methylpiperidin-4-yl)phenyl)amino)-2,3-dihydropyrimido[4,5-d]pyrimidin-4(1H)-one

InChi Key: VWHNEYAANMETIA-UHFFFAOYSA-N

InChi Code: InChI=1S/C26H28Cl2N6O/c1-16-13-18(7-8-19(16)17-9-11-32(2)12-10-17)30-26-29-14-20-24(31-26)33(3)15-34(25(20)35)23-21(27)5-4-6-22(23)28/h4-8,13-14,17H,9-12,15H2,1-3H3,(H,29,30,31)

SMILES Code: CC1=C(C=CC(=C1)NC2=NC=C3C(=N2)N(CN(C3=O)C4=C(C=CC=C4Cl)Cl)C)C5CCN(CC5)C

Appearance: To be determined

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 511.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Matheson CJ, Backos DS, Reigan P. Targeting WEE1 Kinase in Cancer. Trends
Pharmacol Sci. 2016 Oct;37(10):872-881. doi: 10.1016/j.tips.2016.06.006. Epub
2016 Jul 14. PMID: 27427153.

2: Kong A, Mehanna H. WEE1 Inhibitor: Clinical Development. Curr Oncol Rep. 2021
Jul 16;23(9):107. doi: 10.1007/s11912-021-01098-8. PMID: 34269904; PMCID:
PMC8285350.

3: Ghelli Luserna di Rorà A, Cerchione C, Martinelli G, Simonetti G. A WEE1
family business: regulation of mitosis, cancer progression, and therapeutic
target. J Hematol Oncol. 2020 Sep 21;13(1):126. doi: 10.1186/s13045-020-00959-2.
PMID: 32958072; PMCID: PMC7507691.

4: Koh SB. The expanding role of WEE1. Cell Signal. 2022 Jun;94:110310. doi:
10.1016/j.cellsig.2022.110310. Epub 2022 Mar 16. PMID: 35304285.

5: Shi L, Xue X, Tian H, Ye H, Wang H, Wang R, Liu Y, Zhang C, Chen Q, Sun L.
WEE1 promotes endometriosis via the Wnt/β-catenin signaling pathway. Reprod Biol
Endocrinol. 2021 Oct 22;19(1):161. doi: 10.1186/s12958-021-00844-8. PMID:
34686198; PMCID: PMC8532311.