WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H123091
CAS#: 733043-41-9
Description: BCH-24426 is a PDE3 inhibitor.
Hodoodo Cat#: H123091
Name: BCH-24426
CAS#: 733043-41-9
Chemical Formula: C10H7Cl2N3O2
Exact Mass: 270.99
Molecular Weight: 272.090
Elemental Analysis: C, 44.14; H, 2.59; Cl, 26.06; N, 15.44; O, 11.76
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Synonym: BCH-24426; BCH24426; BCH 24426; 3-Hydroxy Anagrelide
IUPAC/Chemical Name: 6,7-dichloro-3-hydroxy-1,5-dihydroimidazo[2,1-b]quinazolin-2(3H)-one
InChi Key: KAXTUTDKZVOONF-UHFFFAOYSA-N
InChi Code: InChI=1S/C10H7Cl2N3O2/c11-5-1-2-6-4(7(5)12)3-15-9(17)8(16)14-10(15)13-6/h1-2,9,17H,3H2,(H,13,14,16)
SMILES Code: O=C1C(O)N2CC3=C(Cl)C(Cl)=CC=C3N=C2N1
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 272.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Takei H, Edahiro Y, Mano S, Masubuchi N, Mizukami Y, Imai M, Morishita S,
Misawa K, Ochiai T, Tsuneda S, Endo H, Nakamura S, Eto K, Ohsaka A, Araki M,
Komatsu N. Skewed megakaryopoiesis in human induced pluripotent stem cell-
derived haematopoietic progenitor cells harbouring calreticulin mutations. Br J
Haematol. 2018 Jun;181(6):791-802. doi: 10.1111/bjh.15266. Epub 2018 May 9.
PMID: 29741776.
2.Wang G, Franklin R, Hong Y, Erusalimsky JD. Comparison of the biological activities of anagrelide and its major metabolites in haematopoietic cell cultures. Br J Pharmacol. 2005 Oct;146(3):324-32. doi: 10.1038/sj.bjp.0706341. PMID: 16041400; PMCID: PMC1576287.