WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130355
CAS#: N/A
Description: CBTF is a a heterobifunctional reagent that is often used for the conjugation of antibodies, participating in amine-to-thiol coupling reactions. The 3-arylpropionitrile (APN) group of CBTF allows for the production of stable conjugates.
Hodoodo Cat#: H130355
Name: CBTF
CAS#: N/A
Chemical Formula: C16H4F4NNaO5S
Exact Mass: 420.96
Molecular Weight: 421.250
Elemental Analysis: C, 45.62; H, 0.96; F, 18.04; N, 3.33; Na, 5.46; O, 18.99; S, 7.61
Synonym: CBTF; Sodium 4-((4-(cyanoethynyl)benzoyl)oxy)-2,3,5,6-tetrafluorobenzenesulfonate; APN-TFS ester
IUPAC/Chemical Name: sodium 4-((4-(cyanoethynyl)benzoyl)oxy)-2,3,5,6-tetrafluorobenzenesulfonate
InChi Key: YFJYSJRZDOWXDH-UHFFFAOYSA-M
InChi Code: InChI=1S/C16H5F4NO5S.Na/c17-10-12(19)15(27(23,24)25)13(20)11(18)14(10)26-16(22)9-5-3-8(4-6-9)2-1-7-21;/h3-6H,(H,23,24,25);/q;+1/p-1
SMILES Code: O=C(C1=CC=C(C=C1)C#CC#N)OC2=C(C(F)=C(C(F)=C2F)S(=O)(O[Na])=O)F
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 421.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Kolodych S, Koniev O, Baatarkhuu Z, Bonnefoy JY, Debaene F, Cianférani S, Van Dorsselaer A, Wagner A. CBTF: new amine-to-thiol coupling reagent for preparation of antibody conjugates with increased plasma stability. Bioconjug Chem. 2015 Feb 18;26(2):197-200. doi: 10.1021/bc500610g. Epub 2015 Jan 23. PMID: 25614935.