WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H123116
CAS#: N/A
Description: CIDD-99 is capsazepine (CPZ) analogue with potential antitumor activity. CIDD-99, with dramatic anti-tumor effects against OSCC that may be efficacious as a lone therapy or in combination with standard therapies.
Hodoodo Cat#: H123116
Name: CIDD-99
CAS#: N/A
Chemical Formula: C24H23ClN2O2S
Exact Mass: 438.12
Molecular Weight: 438.970
Elemental Analysis: C, 65.67; H, 5.28; Cl, 8.08; N, 6.38; O, 7.29; S, 7.30
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Synonym: CIDD-99; CIDD 99; CIDD99
IUPAC/Chemical Name: N-(4-chlorophenethyl)-6,7-dihydroxy-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carbothioamide
InChi Key: WZUPRTOAYRBQAC-UHFFFAOYSA-N
InChi Code: InChI=1S/C24H23ClN2O2S/c25-19-8-6-16(7-9-19)10-12-26-24(30)27-13-11-18-14-21(28)22(29)15-20(18)23(27)17-4-2-1-3-5-17/h1-9,14-15,23,28-29H,10-13H2,(H,26,30)
SMILES Code: OC1=C(O)C=C(CCN(C(NCCC2=CC=C(Cl)C=C2)=S)C3C4=CC=CC=C4)C3=C1
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 438.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Sun Y, Zboril EK, De La Chapa JJ, Chai X, Da Conceicao VN, Valdez MC, McHardy
SF, Gonzales CB, Singh BB. Inhibition of Ca2+ entry by capsazepine
analog CIDD-99 prevents oral squamous carcinoma cell proliferation. Front
Physiol. 2022 Sep 15;13:969000. doi: 10.3389/fphys.2022.969000. PMID: 36187775;
PMCID: PMC9521718.
2: De La Chapa JJ, Singha PK, Self KK, Sallaway ML, McHardy SF, Hart MJ, McGuff
HS, Valdez MC, Ruiz F 2nd, Polusani SR, Gonzales CB. The novel capsazepine
analog, CIDD-99, significantly inhibits oral squamous cell carcinoma in vivo
through a TRPV1-independent induction of ER stress, mitochondrial dysfunction,
and apoptosis. J Oral Pathol Med. 2019 May;48(5):389-399. doi:
10.1111/jop.12843. Epub 2019 Apr 4. PMID: 30825343; PMCID: PMC6506371.
