WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130368
CAS#: 2245697-87-2
Description: Pomalidomide-PEG2-C2-NH2 HCl, a functionalized cereblon ligand, has applications in the development of pomalidomide-based PROTACs, furthermore playing a key role in the development of a protein degrader library. The amine group on Pomalidomide-PEG2-C2-NH2 HCl has been shown to lead to the rapid conjugation with carboxyl linkers through the process of coupling reactions.
Hodoodo Cat#: H130368
Name: Pomalidomide-PEG2-C2-NH2 HCl
CAS#: 2245697-87-2
Chemical Formula: C19H25ClN4O6
Exact Mass: 440.15
Molecular Weight: 440.880
Elemental Analysis: C, 51.76; H, 5.72; Cl, 8.04; N, 12.71; O, 21.77
Synonym: Pomalidomide-PEG2-C2-NH2 HCl; Pomalidomide-PEG2-C2-NH2 hydrochloride; Pomalidomide 4'-PEG2-amine
IUPAC/Chemical Name: 4-((2-(2-(2-aminoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride
InChi Key: BIBZEYIXXZHGNZ-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H24N4O6.ClH/c20-6-8-28-10-11-29-9-7-21-13-3-1-2-12-16(13)19(27)23(18(12)26)14-4-5-15(24)22-17(14)25;/h1-3,14,21H,4-11,20H2,(H,22,24,25);1H
SMILES Code: NCCOCCOCCNC1=C2C(N(C3CCC(NC3=O)=O)C(C2=CC=C1)=O)=O.Cl
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 440.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |