WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H123113
CAS#: N/A
Description: RFP151 is a new capsaicin-like analogue. RPF151 downregulated p21 and cyclins A, D1, and D3, leading to S-phase arrest and apoptosis. Although RPF151 has induced the activation of TRPV-1 and TRAIL-R1/DR4 and TRAIL-2/DR5 on the surface of MDA-MB-231 cells, its in vivo antitumor activity was TRPV-1-independent, thus suggesting that RPF151 should not have the same pungency-based limitation of capsaicin. In silico analysis corroborated the biological findings, showing that RPF151 has physicochemical improvements over capsaicin. Overall, the activity of RPF151 against MDA-MB-231 and its lower pungency suggest that it may have a relevant role in cancer therapy.
Hodoodo Cat#: H123113
Name: RPF151
CAS#: N/A
Chemical Formula: C12H17NO4S
Exact Mass: 271.09
Molecular Weight: 271.330
Elemental Analysis: C, 53.12; H, 6.32; N, 5.16; O, 23.59; S, 11.82
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Synonym: RPF151; RPF-151; RPF 151
IUPAC/Chemical Name: N-(benzo[d][1,3]dioxol-5-ylmethyl)butane-1-sulfonamide
InChi Key: KREHHXQCESWPEP-UHFFFAOYSA-N
InChi Code: InChI=1S/C12H17NO4S/c1-2-3-6-18(14,15)13-8-10-4-5-11-12(7-10)17-9-16-11/h4-5,7,13H,2-3,6,8-9H2,1H3
SMILES Code: O=S(NCC1=CC=C2C(OCO2)=C1)(CCCC)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 271.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Ferreira AK, Tavares MT, Pasqualoto KF, de Azevedo RA, Teixeira SF, Ferreira-Junior WA, Bertin AM, de-Sá-Junior PL, Barbuto JA, Figueiredo CR, Cury Y, Damião MC, Parise-Filho R. RPF151, a novel capsaicin-like analogue: in vitro studies and in vivo preclinical antitumor evaluation in a breast cancer model. Tumour Biol. 2015 Sep;36(9):7251-67. doi: 10.1007/s13277-015-3441-z. Epub 2015 Apr 20. PMID: 25894379.