WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H123111
CAS#: N/A
Description: SLB1122168 is a potent inhibitor (IC50 = 94 ± 6 nM) of Spns2-mediated S1P release. Administration of SLB1122168 to mice and rats resulted in a dose dependent decrease in circulating lymphocytes, a pharmacodynamic indication of Spns2 inhibition. SLB1122168 provides a valuable tool compound to explore both the therapeutic potential of targeting Spns2 and the physiologic consequences of selective S1P export inhibition.
Hodoodo Cat#: H123111
Name: SLB1122168 HCl
CAS#: N/A
Chemical Formula: C22H36ClN3O
Exact Mass: 393.25
Molecular Weight: 394.000
Elemental Analysis: C, 67.07; H, 9.21; Cl, 9.00; N, 10.67; O, 4.06
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Synonym: SLB1122168; SLB-1122168; SLB 1122168
IUPAC/Chemical Name: (S)-6-decyl-N-(pyrrolidin-3-ylmethyl)benzo[d]oxazol-2-amine hydrochloride
InChi Key: VVHUHNZYNZOTEH-FYZYNONXSA-N
InChi Code: InChI=1S/C22H35N3O.ClH/c1-2-3-4-5-6-7-8-9-10-18-11-12-20-21(15-18)26-22(25-20)24-17-19-13-14-23-16-19;/h11-12,15,19,23H,2-10,13-14,16-17H2,1H3,(H,24,25);1H/t19-;/m0./s1
SMILES Code: CCCCCCCCCCC1=CC=C2N=C(NC[C@@H]3CNCC3)OC2=C1.[H]Cl
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 394.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Burgio AL, Shrader CW, Kharel Y, Huang T, Salamoun JM, Lynch KR, Santos WL. 2-Aminobenzoxazole Derivatives as Potent Inhibitors of the Sphingosine-1-Phosphate Transporter Spinster Homolog 2 (Spns2). J Med Chem. 2023 Apr 3. doi: 10.1021/acs.jmedchem.3c00149. Epub ahead of print. PMID: 37010497.