WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H525553
CAS#: 72877-72-6
Description: LY 87130 is an inhibitor of phenylethanolamine-N-methyltransferase.
Hodoodo Cat#: H525553
Name: LY 87130
CAS#: 72877-72-6
Chemical Formula: C12H14ClN
Exact Mass: 0.00
Molecular Weight: 207.700
Elemental Analysis: C, 69.39; H, 6.79; Cl, 17.07; N, 6.74
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Synonym: LY 87130; LY87130; LY-87130.
IUPAC/Chemical Name: 2,3,4,5-Tetrahydro-1H-indeno(1,2-c)pyridine hydrochloride
InChi Key: YYDDAWDCRFXJNY-UHFFFAOYSA-N
InChi Code: InChI=1S/C12H13N.ClH/c1-2-4-11-9(3-1)7-10-5-6-13-8-12(10)11;/h1-4,13H,5-8H2;1H
SMILES Code: [H]Cl.C12=C(CC3=C2C=CC=C3)CCNC1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 207.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Routledge C, Marsden CA. Comparison of the effects of selected drugs on the release of hypothalamic adrenaline and noradrenaline measured in vivo. Brain Res. 1987 Nov 17;426(1):103-11. PubMed PMID: 2446707.
2: Routledge C, Marsden CA. Adrenaline in the CNS: in vivo evidence for a functional pathway innervating the hypothalamus. Neuropharmacology. 1987 Jul;26(7B):823-30. Review. PubMed PMID: 2889157.
3: Coen CW, Simonyi A, Fekete MI. Effect of phenylethanolamine N-methyltransferase inhibition on serum concentrations of luteinizing hormone, follicle stimulating hormone and prolactin in pro-oestrous and ovariectomized rats. Brain Res. 1985 Sep 23;343(2):383-7. PubMed PMID: 3931859.
4: Fuller RW, Molloy BB, Hemrick SK, Perry KW. Inhibition of rat brain norepinephrine N-methyltransferase by 2,3,4,5-tetrahydro-1H-indeno [1,2-c]pyridine hydrochloride (LY87130). Brain Res. 1980 May 19;190(1):215-23. PubMed PMID: 7378735.