WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H123132
CAS#: N/A
Description: UCM-14216 is a LPA2 antagonist
Hodoodo Cat#: H123132
Name: UCM-14216
CAS#: N/A
Chemical Formula: C18H14Cl2N6O3
Exact Mass: 432.05
Molecular Weight: 433.250
Elemental Analysis: C, 49.90; H, 3.26; Cl, 16.36; N, 19.40; O, 11.08
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Synonym: UCM-14216; UCM14216; UCM 14216; GLXC-26113;
IUPAC/Chemical Name: 5-((2H-tetrazol-5-yl)methoxy)-2-(4-(2,4-dichlorophenoxy)-5-methyl-1H-pyrazol-3-yl)phenol
InChi Key: RZGVUGDKIXTIMM-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H14Cl2N6O3/c1-9-18(29-15-5-2-10(19)6-13(15)20)17(24-21-9)12-4-3-11(7-14(12)27)28-8-16-22-25-26-23-16/h2-7,27H,8H2,1H3,(H,21,24)(H,22,23,25,26)
SMILES Code: OC1=CC(OCC2=NNN=N2)=CC=C1C3=NNC(C)=C3OC4=CC=C(Cl)C=C4Cl
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 433.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Khiar-Fernández N, Zian D, Vázquez-Villa H, Martínez RF, Escobar-Peña A, Foronda-Sainz R, Ray M, Puigdomenech-Poch M, Cincilla G, Sánchez-Martínez M, Kihara Y, Chun J, López-Vales R, López-Rodríguez ML, Ortega-Gutiérrez S. Novel Antagonist of the Type 2 Lysophosphatidic Acid Receptor (LPA2), UCM-14216, Ameliorates Spinal Cord Injury in Mice. J Med Chem. 2022 Aug 25;65(16):10956-10974. doi: 10.1021/acs.jmedchem.2c00046. Epub 2022 Aug 10. PMID: 35948083; PMCID: PMC9421655.