WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H123155
CAS#: N/A
Description: ARN25062 is a CDC42 GTPase Interaction Inhibitor for the Treatment of Cancer
Hodoodo Cat#: H123155
Name: ARN25062
CAS#: N/A
Chemical Formula: C22H21F3N4
Exact Mass: 398.17
Molecular Weight: 398.430
Elemental Analysis: C, 66.32; H, 5.31; F, 14.30; N, 14.06
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Synonym: ARN25062; ARN-25062; ARN 25062
IUPAC/Chemical Name: 6-phenyl-2-(piperidin-4-yl)-N-(3-(trifluoromethyl)phenyl)pyrimidin-4-amine
InChi Key: NGGORHPZMJVKNU-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H21F3N4/c23-22(24,25)17-7-4-8-18(13-17)27-20-14-19(15-5-2-1-3-6-15)28-21(29-20)16-9-11-26-12-10-16/h1-8,13-14,16,26H,9-12H2,(H,27,28,29)
SMILES Code: FC(C1=CC(NC2=NC(C3CCNCC3)=NC(C4=CC=CC=C4)=C2)=CC=C1)(F)F
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 398.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Brindani N, Vuong LM, Acquistapace IM, La Serra MA, Ortega JA, Veronesi M, Bertozzi SM, Summa M, Girotto S, Bertorelli R, Armirotti A, Ganesan AK, De Vivo M. Design, Synthesis, In Vitro and In Vivo Characterization of CDC42 GTPase Interaction Inhibitors for the Treatment of Cancer. J Med Chem. 2023 Apr 7. doi: 10.1021/acs.jmedchem.3c00276. Epub ahead of print. PMID: 37026468.