WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H525558
CAS#: 72332-32-2
Description: LY-104119 is a thermogenic weight-reducing compound. It acutely decreased norepinephrine concentration in interscapular brown adipose tissue, heart and liver.
Hodoodo Cat#: H525558
Name: LY-104119
CAS#: 72332-32-2
Chemical Formula: C19H25ClN2O2
Exact Mass: 348.16
Molecular Weight: 348.870
Elemental Analysis: C, 65.41; H, 7.22; Cl, 10.16; N, 8.03; O, 9.17
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Synonym: LY-104119; LY 104119; LY104119.
IUPAC/Chemical Name: 4-(3(S)-((2(R)-Hydroxy-2-phenylethyl)amino)butyl)benzamide hydrochloride
InChi Key: ZSGXWKSCBQJZSH-DJKAKHFESA-N
InChi Code: InChI=1S/C19H24N2O2.ClH/c1-14(21-13-18(22)16-5-3-2-4-6-16)7-8-15-9-11-17(12-10-15)19(20)23;/h2-6,9-12,14,18,21-22H,7-8,13H2,1H3,(H2,20,23);1H/t14-,18-;/m0./s1
SMILES Code: O=C(N)C1=CC=C(CC[C@@H](NC[C@H](O)C2=CC=CC=C2)C)C=C1.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 348.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Yen TT, Fuller RW, Hemrick-Luecke SK, Dininger NB. Effects of LY104119, a thermogenic weight-reducing compound, on norepinephrine concentrations and turnover in obese and lean mice. Int J Obes. 1988;12(1):59-67. PubMed PMID: 2896179.
2: Sullivan AC, Hogan S, Triscari J. New developments in pharmacological treatments for obesity. Ann N Y Acad Sci. 1987;499:269-76. Review. PubMed PMID: 3300486.
3: Stewart IC, Chapman BJ, Munro JF. Pharmacological approaches to the regulation of fat metabolism. Bibl Nutr Dieta. 1986;(39):16-26. PubMed PMID: 3541889.
4: Yen TT, McKee MM, Stamm NB. Thermogenesis and weight control. Int J Obes. 1984;8 Suppl 1:65-78. PubMed PMID: 6152557.