LY-127210 free base

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H525559

CAS#: 57184-68-6

Description: LY-127210 free base is a novel antihypertensive agent. It is peripheral arterial vasodilator that reduces mean arterial blood.

Chemical Structure

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LY-127210 free base
CAS# 57184-68-6
Instruction

Theoretical Analysis

Hodoodo Cat#: H525559
Name: LY-127210 free base
CAS#: 57184-68-6
Chemical Formula: C12H14N2O2
Exact Mass: 218.11
Molecular Weight: 218.260
Elemental Analysis: C, 66.04; H, 6.47; N, 12.84; O, 14.66

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: LY-127210 free base; LY 127210; LY127210.

IUPAC/Chemical Name: 1H-3-Benzazepin-2-amine, 7,8-dimethoxy-

InChi Key: WADYQLCXAVXCQZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H14N2O2/c1-15-10-5-8-3-4-14-12(13)7-9(8)6-11(10)16-2/h3-6H,7H2,1-2H3,(H2,13,14)

SMILES Code: NC1=NC=CC2=CC(OC)=C(OC)C=C2C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 218.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Petersen BH, Heim MC, White JF. Experimental drug-induced immune thrombocytopenia in monkeys. Diagn Clin Immunol. 1988;5(6):349-54. PubMed PMID: 3064948.

2: Steinberg MI, Keller CE, Bemis KG. Hemodynamic and vascular activity of LY127210, a new vasodilator, in anesthetized spontaneously hypertensive rats: comparison with hydralazine. Clin Exp Hypertens A. 1985;7(10):1481-97. PubMed PMID: 3841035.

3: Ruffolo RR Jr, Kurz K, Paget CJ. Evaluation of a novel antihypertensive agent, LY127210, in anesthetized and conscious spontaneously hypertensive rats. J Pharmacol Exp Ther. 1985 Jan;232(1):134-8. PubMed PMID: 3838104.