WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130385
CAS#: N/A
Description: C5 Lenalidomide-PEG2-Butyl NH2 hydrochloride is a vital component in the synthesis of targeted protein degraders and PROTACs. The conjugate is composed of a Cereblon (CRBN)-recruiting ligand with alternative exit vector, a linker with both hydrophobic and hydrophilic moieties, and a pendant amine that reacts with an acid on the target warhead.
Hodoodo Cat#: H130385
Name: C5 Lenalidomide-PEG2-Butyl NH2 hydrochloride
CAS#: N/A
Chemical Formula: C23H33ClN4O6
Exact Mass: 0.00
Molecular Weight: 496.989
Elemental Analysis: C, 55.59; H, 6.69; Cl, 7.13; N, 11.27; O, 19.32
Synonym: C5 Lenalidomide-PEG2-Butyl NH2 hydrochloride; C5 Lenalidomide-PEG2-Butyl NH2 HCl
IUPAC/Chemical Name: 2-(2-((6-aminohexyl)oxy)ethoxy)-N-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)acetamide hydrochloride
InChi Key: HDOCYCRRBNJXSG-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H32N4O6.ClH/c24-9-3-1-2-4-10-32-11-12-33-15-21(29)25-17-5-6-18-16(13-17)14-27(23(18)31)19-7-8-20(28)26-22(19)30;/h5-6,13,19H,1-4,7-12,14-15,24H2,(H,25,29)(H,26,28,30);1H
SMILES Code: O=C(NC1=CC2=C(C(N(C(CC3)C(NC3=O)=O)C2)=O)C=C1)COCCOCCCCCCN.[H]Cl
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
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The following data is based on the product molecular weight 496.99 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |