WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H123204
CAS#: N/A
Description: Naamidine J is a marine natural product.
Hodoodo Cat#: H123204
Name: Naamidine J
CAS#: N/A
Chemical Formula: C25H27N5O5
Exact Mass: 477.20
Molecular Weight: 477.520
Elemental Analysis: C, 62.88; H, 5.70; N, 14.67; O, 16.75
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: Naamidine J; NaamidineJ; Naamidine-J; J3.538.400F
IUPAC/Chemical Name: 4-((5-(3,4-dimethoxybenzyl)-4-(4-methoxybenzyl)-1-methyl-1H-imidazol-2-yl)amino)-1-methyl-1H-imidazole-2,5-dione
InChi Key: BNRNBQPXQALGJR-UHFFFAOYSA-N
InChi Code: InChI=1S/C25H27N5O5/c1-29-19(13-16-8-11-20(34-4)21(14-16)35-5)18(12-15-6-9-17(33-3)10-7-15)26-24(29)27-22-23(31)30(2)25(32)28-22/h6-11,14H,12-13H2,1-5H3,(H,26,27,28,32)
SMILES Code: CN1C(CC2=CC(OC)=C(OC)C=C2)=C(CC3=CC=C(OC)C=C3)N=C1NC(C(N4C)=O)=NC4=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 477.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Fu PP, Wang Q, Zhang Q, Jin Y, Liu J, Chen KX, Guo YW, Liu SH, Li XW.
Bioactivity-Driven Synthesis of the Marine Natural Product Naamidine J and Its
Derivatives as Potential Tumor Immunological Agents by Inhibiting Programmed
Death-Ligand 1. J Med Chem. 2023 Apr 11. doi: 10.1021/acs.jmedchem.2c01702. Epub
ahead of print. PMID: 37040446.
2: Gong KK, Tang XL, Liu YS, Li PL, Li GQ. Imidazole Alkaloids from the South
China Sea Sponge Pericharax heteroraphis and Their Cytotoxic and Antiviral
Activities. Molecules. 2016 Jan 26;21(2):150. doi: 10.3390/molecules21020150.
PMID: 26821008; PMCID: PMC6274532.
3: Tang WZ, Yang ZZ, Wu W, Tang J, Sun F, Wang SP, Cheng CW, Yang F, Lin HW.
Imidazole Alkaloids and Their Zinc Complexes from the Calcareous Marine Sponge
Leucetta chagosensis. J Nat Prod. 2018 Apr 27;81(4):894-900. doi:
10.1021/acs.jnatprod.7b01006. Epub 2018 Apr 12. PMID: 29648818.
4: An B, Yin F, de Voogd NJ, Chen X, Cheng W, Lin W. Chagosendines A - C, New
Metal Complexes of Imidazole Alkaloids from the Calcareous Sponge Leucetta
chagosensis. Chem Biodivers. 2018 Feb;15(2). doi: 10.1002/cbdv.201700481. Epub
2018 Jan 30. PMID: 29194948.
