WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H123206
CAS#: N/A
Description: V2043, also known as ODBG-P-RVn, is a GS-441524 derivative, and an antiviral agent as a potential oral treatment for SARS-CoV-2. V2043 showed that it inhibits SARS-CoV-2 replication in Huh7.5 cells (EC50 = 138 nM) and is orally bioavailable in Syrian hamsters
Hodoodo Cat#: H123206
Name: V2043
CAS#: N/A
Chemical Formula: C40H62N5O9P
Exact Mass: 787.43
Molecular Weight: 787.940
Elemental Analysis: C, 60.97; H, 7.93; N, 8.89; O, 18.27; P, 3.93
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Synonym: V2043; V 2043; V-2043; ODBG P-RVn; ODBG-P-RVn; ODBG-P RVn; C000718607
IUPAC/Chemical Name: ((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methyl ((R)-2-(benzyloxy)-3-(octadecyloxy)propyl) hydrogen phosphate
InChi Key: JWTGVUMJEVOXGW-RTZKIGCUSA-N
InChi Code: InChI=1S/C40H62N5O9P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-20-25-50-27-33(51-26-32-21-18-17-19-22-32)28-52-55(48,49)53-29-35-37(46)38(47)40(30-41,54-35)36-24-23-34-39(42)43-31-44-45(34)36/h17-19,21-24,31,33,35,37-38,46-47H,2-16,20,25-29H2,1H3,(H,48,49)(H2,42,43,44)/t33-,35-,37-,38-,40+/m1/s1
SMILES Code: O=P(O)(OC[C@@H]1[C@@H](O)[C@@H](O)[C@](C#N)(C2=CC=C3N2N=CN=C3N)O1)OC[C@@H](COCCCCCCCCCCCCCCCCCC)OCC4=CC=CC=C4
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 787.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Lo MK, Shrivastava-Ranjan P, Chatterjee P, Flint M, Beadle JR, Valiaeva N,
Schooley RT, Hostetler KY, Montgomery JM, Spiropoulou C. Broad-spectrum in vitro
antiviral activity of ODBG-P-RVn: an orally-available, lipid-modified
monophosphate prodrug of remdesivir parent nucleoside (GS-441524). bioRxiv
[Preprint]. 2021 Aug 10:2021.08.06.455494. doi: 10.1101/2021.08.06.455494.
Update in: Microbiol Spectr. 2021 Nov 24;:e0153721. PMID: 34401879; PMCID:
PMC8366795.
2: Lo MK, Shrivastava-Ranjan P, Chatterjee P, Flint M, Beadle JR, Valiaeva N,
Murphy J, Schooley RT, Hostetler KY, Montgomery JM, Spiropoulou CF. Broad-
Spectrum In Vitro Antiviral Activity of ODBG-P-RVn: An Orally-Available,
Lipid-Modified Monophosphate Prodrug of Remdesivir Parent Nucleoside
(GS-441524). Microbiol Spectr. 2021 Dec 22;9(3):e0153721. doi:
10.1128/Spectrum.01537-21. Epub 2021 Nov 24. PMID: 34817209; PMCID: PMC8612139.
