WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130394
CAS#: N/A
Description: Alkyne-PEG6-acid, also known as 3,6,9,12,15,18-Hexaoxahexacos-25-ynoic acid, is a heterobifunctional, PEGylated crosslinker with applications in bioconjugation and as a component in the synthesis of small molecules. The crosslinker is bound at one end by a carboxyl group and an alkyne at the other. The crosslinker is referred to as 2-2-2-2-2-2-6 PROTAC® linker when it is incorporated into PROTACs, and is also used in the synthesis antibody-drug conjugates.
Hodoodo Cat#: H130394
Name: Alkyne-PEG6-acid
CAS#: N/A
Chemical Formula: C20H36O8
Exact Mass: 404.24
Molecular Weight: 404.500
Elemental Analysis: C, 59.39; H, 8.97; O, 31.64
Synonym: Alkyne-PEG6-acid; 3,6,9,12,15,18-hexaoxahexacos-25-ynoic acid
IUPAC/Chemical Name: 3,6,9,12,15,18-hexaoxahexacos-25-ynoic acid
InChi Key: YBYFNRMIPKWNPU-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H36O8/c1-2-3-4-5-6-7-8-23-9-10-24-11-12-25-13-14-26-15-16-27-17-18-28-19-20(21)22/h1H,3-19H2,(H,21,22)
SMILES Code: C#CCCCCCCOCCOCCOCCOCCOCCOCC(O)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 404.50 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Lai AC, Toure M, Hellerschmied D, Salami J, Jaime-Figueroa S, Ko E, Hines J, Crews CM. Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL. Angew Chem Int Ed Engl. 2016 Jan 11;55(2):807-10. doi: 10.1002/anie.201507634. Epub 2015 Nov 23. PMID: 26593377; PMCID: PMC4733637.