WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130397
CAS#: N/A
Description: BocA1V2PF1, an inhibitor of the apoptosis protein (IAP)-recruiting ligand, is used in targeted protein degradation and development of SNIPERs (specific and non-genetic IAP-dependent protein erasers).
Hodoodo Cat#: H130397
Name: BocA1V2PF1
CAS#: N/A
Chemical Formula: C30H44N4O7
Exact Mass: 572.32
Molecular Weight: 572.703
Elemental Analysis: C, 62.92; H, 7.74; N, 9.78; O, 19.56
Synonym: BocA1V2PF1
IUPAC/Chemical Name: ((S)-2-((S)-2-((tert-butoxycarbonyl)amino)propanamido)-2-cyclohexylacetyl)-L-prolyl-L-phenylalanine
InChi Key: HVORUACRMULJRJ-HCUBDLJJSA-N
InChi Code: InChI=1S/C30H44N4O7/c1-19(31-29(40)41-30(2,3)4)25(35)33-24(21-14-9-6-10-15-21)27(37)34-17-11-16-23(34)26(36)32-22(28(38)39)18-20-12-7-5-8-13-20/h5,7-8,12-13,19,21-24H,6,9-11,14-18H2,1-4H3,(H,31,40)(H,32,36)(H,33,35)(H,38,39)/t19-,22-,23-,24-/m0/s1
SMILES Code: O=C(O)[C@H](CC1=CC=CC=C1)NC([C@H]2N(C([C@@H](NC([C@@H](NC(OC(C)(C)C)=O)C)=O)C3CCCCC3)=O)CCC2)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 572.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Naito M, Ohoka N, Shibata N. SNIPERs-Hijacking IAP activity to induce protein degradation. Drug Discov Today Technol. 2019 Apr;31:35-42. doi: 10.1016/j.ddtec.2018.12.002. Epub 2019 Jan 14. PMID: 31200857.