WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H526837
CAS#: 883023-03-8
Description: KM10103 is a potent β-cell protector. KM10103 exhibits β-cell-protective activities against ER stress. Endoplasmic reticulum (ER) stress plays an important role in the decline in pancreatic β cell function and mass observed in type 2 diabetes.
Hodoodo Cat#: H526837
Name: KM10103
CAS#: 883023-03-8
Chemical Formula: C19H26N2OS
Exact Mass: 330.18
Molecular Weight: 330.490
Elemental Analysis: C, 69.05; H, 7.93; N, 8.48; O, 4.84; S, 9.70
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Synonym: KM-10103; KM 10103; KM10103.
IUPAC/Chemical Name: 1-((3s,5s,7s)-adamantan-1-yl)-3-(2-(methylthio)benzyl)urea
InChi Key: WPXRUUMUUGRZGQ-MYUHZXPASA-N
InChi Code: InChI=1S/C19H26N2OS/c1-23-17-5-3-2-4-16(17)12-20-18(22)21-19-9-13-6-14(10-19)8-15(7-13)11-19/h2-5,13-15H,6-12H2,1H3,(H2,20,21,22)/t13-,14+,15-,19?
SMILES Code: O=C(NCC1=CC=CC=C1SC)NC23C[C@H]4C[C@@H](C3)C[C@H](C4)C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info: Pancreatic insulin-producing β-cell dysfunction and death plays central roles in the onset and progression of both type 1 and type 2 diabetes. Current antidiabetic drugs cannot halt the ongoing progression of β-cell dysfunction and death. In diabetes, a major cause for the decline in β-cell function and survival is endoplasmic reticulum (ER) stress.
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 330.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Tran, K.; Li, Y.; Duan, H.; Arora, D.; Lim, H. Y.; Wang, W. Identification of Small Molecules That Protect Pancreatic Beta Cells against Endoplasmic Reticulum Stress-Induced Cell Death. ACS Chem. Biol. 2014, 9, 2796−2806.