WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130407
CAS#: N/A
Description: C2-N3 is a clickable PROTAC linker that is vital in the synthesis of Nrf2 degraders.
Hodoodo Cat#: H130407
Name: C2-N3
CAS#: N/A
Chemical Formula: C21H25N7O5
Exact Mass: 455.19
Molecular Weight: 455.480
Elemental Analysis: C, 55.38; H, 5.53; N, 21.53; O, 17.56
This product is not in stock, which may be available by custom synthesis.
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Synonym: C2-N3; C2 N3
IUPAC/Chemical Name: N1-(3-azidopropyl)-N5-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)glutaramide
InChi Key: UURBBXHZTMYPIJ-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H25N7O5/c22-27-24-11-3-10-23-17(29)6-2-7-18(30)25-15-5-1-4-13-14(15)12-28(21(13)33)16-8-9-19(31)26-20(16)32/h1,4-5,16H,2-3,6-12H2,(H,23,29)(H,25,30)(H,26,31,32)
SMILES Code: O=C(NCCCN=[N+]=[N-])CCCC(NC1=CC=CC2=C1CN(C(CC3)C(NC3=O)=O)C2=O)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 455.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Ji J, Ma S, Zhu Y, Zhao J, Tong Y, You Q, Jiang Z. ARE-PROTACs Enable Co-degradation of an Nrf2-MafG Heterodimer. J Med Chem. 2023 Mar 9. doi: 10.1021/acs.jmedchem.2c01909. Epub ahead of print. PMID: 36892138.