WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H526838
CAS#: 302901-13-9
Description: RH01687 is a potent β-cell protector. RH01687 exhibits β-cell-protective activities against ER stress. Endoplasmic reticulum (ER) stress plays an important role in the decline in pancreatic β cell function and mass observed in type 2 diabetes.
Hodoodo Cat#: H526838
Name: RH01687
CAS#: 302901-13-9
Chemical Formula: C12H9ClN6O2S
Exact Mass: 336.02
Molecular Weight: 336.750
Elemental Analysis: C, 42.80; H, 2.69; Cl, 10.53; N, 24.96; O, 9.50; S, 9.52
Synonym: RH01687; RH-01687; RH 01687.
IUPAC/Chemical Name: 3-(4-Chloro-2-nitro-5-pyrrol-1-ylphenyl)sulfanyl-1H-1,2,4-triazol-5-amine
InChi Key: BOVTVNWNYFQVMI-UHFFFAOYSA-N
InChi Code: InChI=1S/C12H9ClN6O2S/c13-7-5-9(19(20)21)10(22-12-15-11(14)16-17-12)6-8(7)18-3-1-2-4-18/h1-6H,(H3,14,15,16,17)
SMILES Code: NC1=NC(SC2=CC(N3C=CC=C3)=C(Cl)C=C2[N+]([O-])=O)=NN1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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In vitro activity: | |
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The following data is based on the product molecular weight 336.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Tran, K.; Li, Y.; Duan, H.; Arora, D.; Lim, H. Y.; Wang, W. Identification of Small Molecules That Protect Pancreatic Beta Cells against Endoplasmic Reticulum Stress-Induced Cell Death. ACS Chem. Biol. 2014, 9, 2796−2806.