WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130419
CAS#: N/A
Description: MH-3 is a melanin-concentrating hormone receptor-1 (MCH-R1) ligand with an IC50 of 7 nM.
Hodoodo Cat#: H130419
Name: MH-3
CAS#: N/A
Chemical Formula: C24H26N2O3
Exact Mass: 390.19
Molecular Weight: 390.480
Elemental Analysis: C, 73.82; H, 6.71; N, 7.17; O, 12.29
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Synonym: MH-3; MH3; MH 3
IUPAC/Chemical Name: (R)-3,5-dimethoxy-N-(1-(naphthalen-2-ylmethyl)pyrrolidin-3-yl)benzamide
InChi Key: IWBPLOCOVVLUIE-OAQYLSRUSA-N
InChi Code: InChI=1S/C24H26N2O3/c1-28-22-12-20(13-23(14-22)29-2)24(27)25-21-9-10-26(16-21)15-17-7-8-18-5-3-4-6-19(18)11-17/h3-8,11-14,21H,9-10,15-16H2,1-2H3,(H,25,27)/t21-/m1/s1
SMILES Code: O=C(N[C@H]1CN(CC2=CC=C3C=CC=CC3=C2)CC1)C4=CC(OC)=CC(OC)=C4
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 390.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Helal MA, Chittiboyina AG, Avery MA. Structure-based design of novel melanin-concentrating hormone receptor-1 ligands based on saturated nitrogen-containing heterocycles. Bioorg Med Chem Lett. 2023 Mar 15;84:129194. doi: 10.1016/j.bmcl.2023.129194. Epub 2023 Feb 20. PMID: 36813053.