WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130435
CAS#: 2208962-35-8
Description: MMV688845 is a RNA polymerase inhibitor and is used against nontuberculous mycobacteria, specifically displaying activity against M. abscessus.
Hodoodo Cat#: H130435
Name: MMV688845
CAS#: 2208962-35-8
Chemical Formula: C24H25N3O3S
Exact Mass: 435.16
Molecular Weight: 435.540
Elemental Analysis: C, 66.19; H, 5.79; N, 9.65; O, 11.02; S, 7.36
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Synonym: MMV688845; MMV 688845; MMV-688845
IUPAC/Chemical Name: (R)-N-(1-((2-morpholinophenyl)amino)-1-oxo-3-phenylpropan-2-yl)thiophene-2-carboxamide
InChi Key: YZLODHPDCSNHTP-HXUWFJFHSA-N
InChi Code: InChI=1S/C24H25N3O3S/c28-23(25-19-9-4-5-10-21(19)27-12-14-30-15-13-27)20(17-18-7-2-1-3-8-18)26-24(29)22-11-6-16-31-22/h1-11,16,20H,12-15,17H2,(H,25,28)(H,26,29)/t20-/m1/s1
SMILES Code: O=C(C1=CC=CS1)N[C@H](CC2=CC=CC=C2)C(NC3=CC=CC=C3N4CCOCC4)=O
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 435.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Synthesis and Characterization of Phenylalanine Amides Active against Mycobacterium abscessus and Other Mycobacteria.
Lang M, Ganapathy US, Mann L, Abdelaziz R, Seidel RW, Goddard R, Sequenzia I, Hoenke S, Schulze P, Aragaw WW, Csuk R, Dick T, Richter A.
J Med Chem. 2023 Apr 13;66(7):5079-5098. doi: 10.1021/acs.jmedchem.3c00009. Epub 2023 Mar 31.
PMID: 37001025
2. In Vitro Profiling of the Synthetic RNA Polymerase Inhibitor MMV688845 against Mycobacterium abscessus.
Mann L, Ganapathy US, Abdelaziz R, Lang M, Zimmerman MD, Dartois V, Dick T, Richter A.
Microbiol Spectr. 2022 Dec 21;10(6):e0276022. doi: 10.1128/spectrum.02760-22. Epub 2022 Nov 15.
PMID: 36377951 Free PMC article.
3. Racemization-free synthesis of Nα-2-thiophenoyl-phenylalanine-2-morpholinoanilide enantiomers and their antimycobacterial activity.
Mann L, Lang M, Schulze P, Halz JH, Csuk R, Hoenke S, Seidel RW, Richter A.
Amino Acids. 2021 Aug;53(8):1187-1196. doi: 10.1007/s00726-021-03044-1. Epub 2021 Jul 14.
PMID: 34259925 Free PMC article.
4. Pathogen Box screening for hit identification against Mycobacterium abscessus.
Jeong J, Kim G, Moon C, Kim HJ, Kim TH, Jang J.
PLoS One. 2018 Apr 26;13(4):e0195595. doi: 10.1371/journal.pone.0195595. eCollection 2018.
PMID: 29698397 Free PMC article.