WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130418
CAS#: 2763260-36-0
Description: NRX-103094 increases the potency of the pSer33/Ser37 β-catenin peptide, increasing the binding affinity of S33E/S37A to β-TrCP.
Hodoodo Cat#: H130418
Name: NRX-103094
CAS#: 2763260-36-0
Chemical Formula: C20H11Cl2F3N2O4S
Exact Mass: 501.98
Molecular Weight: 503.270
Elemental Analysis: C, 47.73; H, 2.20; Cl, 14.09; F, 11.32; N, 5.57; O, 12.72; S, 6.37
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Synonym: NRX-103094; NRX 103094; NRX103094
IUPAC/Chemical Name: 3-(4-((2,6-dichlorophenyl)thio)-2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carboxamido)benzoic acid
InChi Key: HFBGFWJURBVNFD-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H11Cl2F3N2O4S/c21-11-5-2-6-12(22)16(11)32-13-8-14(20(23,24)25)27-18(29)15(13)17(28)26-10-4-1-3-9(7-10)19(30)31/h1-8H,(H,26,28)(H,27,29)(H,30,31)
SMILES Code: O=C(O)C1=CC=CC(NC(C2=C(SC3=C(Cl)C=CC=C3Cl)C=C(C(F)(F)F)NC2=O)=O)=C1
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 503.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Simonetta KR, Taygerly J, Boyle K, Basham SE, Padovani C, Lou Y, Cummins TJ, Yung SL, von Soly SK, Kayser F, Kuriyan J, Rape M, Cardozo M, Gallop MA, Bence NF, Barsanti PA, Saha A. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nat Commun. 2019 Mar 29;10(1):1402. doi: 10.1038/s41467-019-09358-9. PMID: 30926793; PMCID: PMC6441019.