WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H130424
CAS#: 2819989-58-5
Description: PBRM1-BD2 inhibitor 12, also known as PBRM1-BD2-IN-3, is a PBRM1-BD2 inhibitor.
Hodoodo Cat#: H130424
Name: PBRM1-BD2 inhibitor 12
CAS#: 2819989-58-5
Chemical Formula: C14H11ClN2O
Exact Mass: 258.06
Molecular Weight: 258.710
Elemental Analysis: C, 65.00; H, 4.29; Cl, 13.70; N, 10.83; O, 6.18
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Synonym: PBRM1-BD2 inhibitor 12; PBRM1-BD2-IN-3
IUPAC/Chemical Name: 5-chloro-2-phenyl-2,3-dihydroquinazolin-4(1H)-one
InChi Key: ODBQDJLEOQRRNZ-UHFFFAOYSA-N
InChi Code: InChI=1S/C14H11ClN2O/c15-10-7-4-8-11-12(10)14(18)17-13(16-11)9-5-2-1-3-6-9/h1-8,13,16H,(H,17,18)
SMILES Code: O=C1NC(C2=CC=CC=C2)NC3=C1C(Cl)=CC=C3
Appearance: To be determined
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 258.71 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Shishodia S, Nuñez R, Strohmier BP, Bursch KL, Goetz CJ, Olp MD, Jensen DR, Fenske TG, Ordonez-Rubiano SC, Blau ME, Roach MK, Peterson FC, Volkman BF, Dykhuizen EC, Smith BC. Selective and Cell-Active PBRM1 Bromodomain Inhibitors Discovered through NMR Fragment Screening. J Med Chem. 2022 Oct 27;65(20):13714-13735. doi: 10.1021/acs.jmedchem.2c00864. Epub 2022 Oct 13. PMID: 36227159; PMCID: PMC9630929.